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Cat. No.: HY-190645

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COX-2-IN-76

COX-2-IN-76 is an orally active selective COX-2 inhibitor with an IC₅₀ of 0.059 μM. COX-2-IN-76 inhibits prostaglandin synthesis and suppresses NF-κB and IL-6 inflammatory signaling. COX-2-IN-76 exhibits anti-inflammatory effects in the formalin-induced rat paw edema model, reducing paw edema. COX-2-IN-76 can be used for research on inflammation-related diseases.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₀N₆O₂S
Molecular Weight:468.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-76 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

COX-2

NF-κB

IL-6

All COX Isoforms :

All NF-κB Isoforms :

All Interleukin Related Isoforms :

In Vitro

Innate ImmunityLipid Inflammatory Mediators

Innate Immunity

Lipid Inflammatory Mediators

COX-2-IN-76 (compound 8I) is a potent and selective COX-2 inhibitor in cell-free assays using sheep COX-1 and human recombinant COX-2, with a COX-2 IC₅₀ = 0.059 μM and a selectivity index of 153.05^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityCytokines & Chemokines

Innate Immunity

Cytokines & Chemokines

COX-2-IN-76 (compound 8I) (10 mg/kg; p.o.; once daily; for 7 consecutive days) attenuates formalin-induced paw edema with potency exceeding that of Indomethacin (HY-14397) and Celecoxib (HY-14398), and reduces NF-κB, COX-2, and IL-6 levels in paw tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, adult)^[1]
Dosage:

10 mg/kg
Administration:

p.o. (gastric gavage); once daily; 7 consecutive days
Result:

Attenuated formalin-induced paw edema with potency exceeding that of Indomethacin (HY-14397) and Celecoxib (HY-14398).
Reduced paw‑tissue NF‑κB by 2.4‑2.6‑fold, COX‑2 by 2.3‑2.5‑fold, and IL‑6 by 2.2‑2.5‑fold relative to the paw‑edema group.

Related Protocols :

Chemical Information

Molecular Weight 468.53
Formula C₂₅H₂₀N₆O₂S
SMILES

O=C(C1=C2N=CC=C(C3=CC=CS3)N2N=C1NC4=CC=CC=C4)N/N=C/C5=CC=C(OC)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Helmy A O M, et al. Design, synthesis, structure–activity relationship and in-silico studies of novel pyrazolo[1,5-a]pyrimidine derivatives as selective COX-2 inhibitors with promising anti-inflammatory activity and safety profile. Bioorganic Chemistry. 2026;182:110547.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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COX-2-IN-76

All COX Isoforms

All NF-κB Isoforms

All Interleukin Related Isoforms