NA 0345
NA 0345 is a PKC inhibitor with IC50 values of 70 nM and 110 nM in the presence and absence of 12-O-tetradecanoyl-13-acetate, respectively. NA 0345 inhibits PKC and selectively suppresses the positive inotropic effect mediated by α1-adrenergic receptors.
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- CAS. Nr.: 120925-60-2
- Formel: C27H24N4O3
- Molecular Weight:452.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
NA 0345 (10-100 nM) selectively inhibits the α1-adrenoceptor-mediated positive inotropic effect in isolated rabbit papillary muscles, without affecting the β-adrenoceptor-mediated positive inotropic effect[1].
NA 0345 (10-100 nM) does not affect α1-adrenoceptor-mediated IP1 accumulation in isolated rabbit ventricular slices[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 120925-60-2
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Molecular Weight 452.50
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Formel C27H24N4O3
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SMILES
O=C1NCC2=C(C3=C(N4[C@]5(C)OC6C[C@]5(CNC)O)C=CC=C3)C4=C7N6C8=CC=CC=C8C7=C21
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NA 0345 Related Classifications
HY-165397 Related Classifications
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