rel-Avibactam

Avibactam potently inhibits Ambler class A, class C, and some class D β-lactamases, with a turnover number of 1. It exhibits superior potency to existing β-lactamase inhibitors, with particularly prominent inhibitory activity against the KPC enzyme^[1].
Avibactam (4 μg/mL) significantly enhances the in vitro activity of Ceftazidime (HY-B0593) against Enterobacteriaceae and Pseudomonas aeruginosa (including Ceftazidime-resistant strains), but does not potentiate the activity of Ceftazidime against Acinetobacter baumannii, Burkholderia cepacia, or Stenotrophomonas maltophilia^[1].
Avibactam (4 μg/mL) enhances the in vitro activity of Ceftazidime against Prevotella/Porphyromonas species and Fusobacterium species, but does not enhance the activity of Ceftazidime against most Bacteroides species^[1].
Avibactam (5 min) potently inhibits purified TEM-1 β-lactamase from Escherichia coli (IC₅₀ = 8 nM) and purified P99 β-lactamase from Enterobacter cloacae 293HT6 (IC₅₀ = 80 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.