RALBP1 - ralA binding protein 1 Gene

Also Known as RIP1; RLIP1; RLIP76

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10928

About RALBP1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,475,009-9,538,114 (from NCBI)

This gene has 6 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in kidney (RPKM 28.4), skin (RPKM 27.5) and 25 other tissues.

Summary

RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by Ras (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

RALBP1 Products (1)

mRNA	Protein	Name
NM_006788.4	NP_006779.1	ralA-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase-coupled transmembrane transporter activity	IDA IDA: Inferred from direct assay	10924126	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	7673236	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9422736	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	7673236	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	10924126	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	10924126	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in doxorubicin transport	IDA IDA: Inferred from direct assay	10924126	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	7673236	GOA
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	21822277	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21822277	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	7673236	GOA
involved in small GTPase-mediated signal transduction	IPI IPI: Inferred from physical interaction	7673236	GOA
involved in transmembrane transport	IDA IDA: Inferred from direct assay	10924126	GOA
involved in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA IDA: Inferred from direct assay	10924126	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	10924126	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	21822277	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RALBP1 Protein Structure

RhoGAP

0
200
400
600
655 a.a.

Protein Preferred Names	Protein Names
ralA-binding protein 1	76 kDa Ral-interacting protein

RALBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RALBP1	Q15311	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	RALBP1	Q15311	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	RALBP1	Q15311	TFPT	Homo sapiens	P0C1Z6-2	Validated Y2H	25416956
Intra	RALBP1	Q15311	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	RALBP1	Q15311	TBRG1	Homo sapiens	Q05BL0	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	TBRG1	Homo sapiens	Q05BL0	Y2H Array	25416956
Intra	RALBP1	Q15311	q9h6f0_human	Homo sapiens	Q9H6F0	Y2H Array	25416956
Intra	RALBP1	Q15311	q9h6f0_human	Homo sapiens	Q9H6F0	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	q9h6f0_human	Homo sapiens	Q9H6F0	Validated Y2H	25416956
Intra	RALBP1	Q15311	RALA	Homo sapiens	P11233	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	RALA	Homo sapiens	P11233	Anti Bait CoIP	28851898
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Y2H Array	32296183
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Validated Y2H	32296183
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Anti Tag CoIP	32203420
Intra	RALBP1	Q15311	CCDC6	Homo sapiens	Q16204	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	RALBP1	Q15311	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	RALBP1	Q15311	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	RALBP1	Q15311	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	RALBP1	Q15311	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	RALBP1	Q15311	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	RALBP1	Q15311	REPS1	Homo sapiens	Q96D71	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	REPS1	Homo sapiens	Q96D71	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	REPS1	Homo sapiens	Q96D71	Anti Tag CoIP	32203420
Intra	RALBP1	Q15311	REPS1	Homo sapiens	Q96D71	Anti Tag CoIP	35271311
Intra	RALBP1	Q15311	PCM1	Homo sapiens	Q15154-3	Y2H Array	32296183
Intra	RALBP1	Q15311	PCM1	Homo sapiens	Q15154-3	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	RALBP1	Q15311	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	RALBP1	Q15311	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	RALBP1	Q15311	SAPCD2	Homo sapiens	Q86UD0	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	SAPCD2	Homo sapiens	Q86UD0	Validated Y2H	32296183
Intra	RALBP1	Q15311	SAPCD2	Homo sapiens	Q86UD0	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	SAPCD2	Homo sapiens	Q86UD0	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	RALBP1	Q15311	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	RALBP1	Q15311	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	RALBP1	Q15311	VHL	Homo sapiens	P40337-3	Pull Down	28580172
Intra	RALBP1	Q15311	CEP57	Homo sapiens	Q86XR8	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	CEP57	Homo sapiens	Q86XR8	Validated Y2H	25416956
Intra	RALBP1	Q15311	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	RALBP1	Q15311	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RALBP1	Q15311	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RALBP1	Q15311	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RALBP1	Q15311	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	RALBP1	Q15311	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	RALBP1	Q15311	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	RALBP1	Q15311	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RALBP1	Q15311	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RALBP1	Q15311	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RALBP1	Q15311	DLG1	Homo sapiens	Q12959	Phage Display	24550280
Intra	RALBP1	Q15311	DLG1	Homo sapiens	Q12959	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	RALBP1	Q15311	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	RALBP1	Q15311	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	PPL	Homo sapiens	O60437	Validated Y2H	25416956
Intra	RALBP1	Q15311	PPL	Homo sapiens	O60437	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	PPL	Homo sapiens	O60437	Y2H Array	25416956
Intra	RALBP1	Q15311	GSE1	Homo sapiens	Q14687	Y2H Array	29892012
Intra	RALBP1	Q15311	GSE1	Homo sapiens	Q14687	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	GSE1	Homo sapiens	Q14687	Y2H Array	25416956
Intra	RALBP1	Q15311	CCL20	Homo sapiens	P78556	Anti Tag CoIP	18239685
Intra	RALBP1	Q15311	TCP10L	Homo sapiens	Q8TDR4	Validated Y2H	32296183
Intra	RALBP1	Q15311	TCP10L	Homo sapiens	Q8TDR4	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	TCP10L	Homo sapiens	Q8TDR4	Y2H Array	32296183
Intra	RALBP1	Q15311	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	RALBP1	Q15311	CREBZF	Homo sapiens	Q9NS37	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	CREBZF	Homo sapiens	Q9NS37	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	CREBZF	Homo sapiens	Q9NS37	Validated Y2H	32296183
Intra	RALBP1	Q15311	CREBZF	Homo sapiens	Q9NS37	Y2H Array	32296183
Intra	RALBP1	Q15311	CREBZF	Homo sapiens	Q9NS37	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	32296183
Intra	RALBP1	Q15311	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	32296183
Intra	RALBP1	Q15311	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Validated Y2H	25416956
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Y2H Array	25416956
Intra	RALBP1	Q15311	GPS2	Homo sapiens	Q13227	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	RALBP1	Q15311	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	HOOK2	Homo sapiens	Q96ED9	Anti Tag CoIP	31980649
Intra	RALBP1	Q15311	HOOK2	Homo sapiens	Q96ED9	Y2H Pooling	16189514
Intra	RALBP1	Q15311	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	RALBP1	Q15311	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	RALBP1	Q15311	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	RALBP1	Q15311	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
Intra	RALBP1	Q15311	ZNF707	Homo sapiens	Q96C28	Validated Y2H	25416956
Intra	RALBP1	Q15311	ZNF707	Homo sapiens	Q96C28	Validated Y2H	32296183
Intra	RALBP1	Q15311	MSANTD4	Homo sapiens	Q8NCY6	Validated Y2H	32296183
Intra	RALBP1	Q15311	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
Intra	RALBP1	Q15311	MSANTD4	Homo sapiens	Q8NCY6	Anti Tag CoIP	33961781
Intra	RALBP1	Q15311	MSANTD4	Homo sapiens	Q8NCY6	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	DLG4	Homo sapiens	P78352	Y2H Pooling	21653829
Intra	RALBP1	Q15311	CBY1	Homo sapiens	Q9Y3M2	Anti Tag CoIP	28514442
Intra	RALBP1	Q15311	CBY1	Homo sapiens	Q9Y3M2	Validated Y2H	32296183
Intra	RALBP1	Q15311	CBY1	Homo sapiens	Q9Y3M2	Y2H Prey Pooling	32296183
Intra	RALBP1	Q15311	CBY1	Homo sapiens	Q9Y3M2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RALBP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83308	RALBP1 Antibody (YA3053)	WB, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125987	RBC6	Inhibitor	98.88%	Unkown
HY-123464	RBC10	Inhibitor	98.0%	Unkown
HY-RS11629	RALBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11845	REPS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18714	Ralbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25201	Ralbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RALBP1	VGNC	VGNC:104240
Bos taurus	RALBP1	VGNC	VGNC:33700
Rattus norvegicus	RALBP1	RGD	RGD:621134
Canis familiaris	RALBP1	VGNC	VGNC:45332
Felis catus	RALBP1	VGNC	VGNC:69229
Mus musculus	RALBP1	MGD	MGI:108466
Others	RALBP1	NCBI