TNK1 - tyrosine kinase non receptor 1 Gene

Also Known as KOS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8711

About TNK1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,380,047-7,389,742 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 88 orthologues and 32 paralogues. Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TNK1 Products (2)

mRNA Protein Name
NM_001251902.3 NP_001238831.1 non-receptor tyrosine-protein kinase TNK1 isoform 1
NM_003985.6 NP_003976.2 non-receptor tyrosine-protein kinase TNK1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10873601 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10873601 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10873601 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
10873601 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10873601 GOA
located in membrane IDA
IDA: Inferred from direct assay
10873601 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNK1 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (119 - 374)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

non-receptor tyrosine-protein kinase TNK1

  • CD38 negative kinase 1

TNK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNK1 Q13470 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
TNK1 Q13470 YWHAE Homo sapiens P62258
Anti Tag CoIP
25852190
Intra
TNK1 Q13470 SFN Homo sapiens P31947
TAP
15778465
Intra
TNK1 Q13470 SFN Homo sapiens P31947
Anti Tag CoIP
25852190
Cross: Cross-species interaction Intra: Intraspecies interaction

TNK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85392 TNK1 Antibody (YA5084) WB, ELISA Human

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-147316 TP-5801 Inhibitor 98.55% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.55% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNK1 VGNC VGNC:78600
Bos taurus TNK1 VGNC VGNC:36182
Rattus norvegicus TNK1 RGD RGD:1310113
Canis familiaris TNK1 VGNC VGNC:47679
Mus musculus TNK1 MGD MGI:1930958
Felis catus TNK1 VGNC VGNC:66419
Others TNK1 NCBI