Ricasetron
Based on 1 Customer Validation
Ricasetron (BRL-46470) is a selective and orally active 5-HT3 receptor antagonist. Ricasetron displays little or no affinity for a variety of other neurotransmitter receptors. Ricasetron has anxiolytic and antiemetic effects.
For research use only. We do not sell to patients.
- Purity: 98.62%
- CAS No.: 117086-68-7
- Formula: C19H27N3O
- Molecular Weight:313.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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5-HT3 Receptor |
In rat cerebral cortex/hippocampus, rat ileum, NG108-15 cell and HEK-5-HT3As cell homogenates, Ricasetron (BRL-46470) binds with high affinity (Kd (nM): 1.57, 2.49, 1.84 , 3.46, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 mice (40-44 g)[2]
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Dosage:10 μg/kg
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Administration:Drinking water; for 12-14 days
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Result:Increased the occurrence of the social act, "nose" and enhanced digging of the unfamiliar sawdust, at the expense of exploration.
Enhanced some acts of aggression.
Chemical Information
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CAS No. 117086-68-7
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Appearance Solid
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Molecular Weight 313.44
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Formula C19H27N3O
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Color Light yellow to yellow
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SMILES
O=C(N1C(C=CC=C2)=C2C(C)(C)C1)N[C@H]3C[C@@H](CC4)N(C)[C@@H]4C3
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Synonyms
BRL-46470
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (159.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Steward LJ, et al. Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron. Br J Pharmacol. 1995 Sep;116(2):1781-8. [Content Brief]
[2]. Gao B, et al. Effects of sub-chronic treatment with chlordiazepoxide, buspirone and the 5-HT3 receptor antagonist, BRL 46470, on the social behaviour of mice. Neuropharmacology. 1992 Mar;31(3):207-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1904 mL | 15.9520 mL | 31.9040 mL | 79.7601 mL |
| 5 mM | 0.6381 mL | 3.1904 mL | 6.3808 mL | 15.9520 mL | |
| 10 mM | 0.3190 mL | 1.5952 mL | 3.1904 mL | 7.9760 mL | |
| 15 mM | 0.2127 mL | 1.0635 mL | 2.1269 mL | 5.3173 mL | |
| 20 mM | 0.1595 mL | 0.7976 mL | 1.5952 mL | 3.9880 mL | |
| 25 mM | 0.1276 mL | 0.6381 mL | 1.2762 mL | 3.1904 mL | |
| 30 mM | 0.1063 mL | 0.5317 mL | 1.0635 mL | 2.6587 mL | |
| 40 mM | 0.0798 mL | 0.3988 mL | 0.7976 mL | 1.9940 mL | |
| 50 mM | 0.0638 mL | 0.3190 mL | 0.6381 mL | 1.5952 mL | |
| 60 mM | 0.0532 mL | 0.2659 mL | 0.5317 mL | 1.3293 mL | |
| 80 mM | 0.0399 mL | 0.1994 mL | 0.3988 mL | 0.9970 mL | |
| 100 mM | 0.0319 mL | 0.1595 mL | 0.3190 mL | 0.7976 mL |
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