EGFR/CDK2-IN-2
EGFR/CDK2-IN-2 (compound 6a) is a dual inhibitor of EGFR and CDK-2 with IC50s of 19.6 and 87.9 nM, respectively. EGFR/CDK2-IN-2 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-2 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 0.39 μM.
For research use only. We do not sell to patients.
- Formula: C49H32N12O2S2
- Molecular Weight:884.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
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Biological Activity
IC50: 19.6 (EGFR), 87.9 nM (CDK-2)[1]
Chemical Information
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Molecular Weight 884.99
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Formula C49H32N12O2S2
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SMILES
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=NN4C(SC3)=NN=C4CC5=NN=C6SCC(C7=NN(C8=CC=CC=C8)C=C7C(C9=CC=C%10C=CC=CC%10=C9)=O)=NN65)C%11=CC=C%12C=CC=CC%12=C%11
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/CDK2-IN-2 Related Classifications
HY-156114 Related Classifications
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