EGFR-IN-137
EGFR-IN-137 (Compound 4c) is an inhibitor for aromatase and EGFR with IC50s of 1.67 μg/mL and 0.08 μg/mL. EGFR-IN-137 inhibits the proliferation of cancer cell MCF-7 and MDA-MB-231 with IC50s of 1.62 µM and 4.14 µM. EGFR-IN-137 arrests the cell cycle at G0/G1 phase in MDA-MB-231, and induces apoptosis through caspase-dependent pathway.
For research use only. We do not sell to patients.
- Formula: C23H21FN6O
- Molecular Weight:416.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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EGFR 0.192 μM (IC50) |
Aromatase 4.01 μM (IC50) |
Chemical Information
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Molecular Weight 416.45
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Formula C23H21FN6O
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SMILES
FC1=CC=C(C=C1)C(NNC2=NC(N3CCCCC3)=NC(C4=CC=CC=C4)=C2C#N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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