EGFR-IN-196
EGFR-IN-196 is an EGFR inhibitor with an IC50 of 105.96 nM. EGFR-IN-196 inhibits EGFR enzymatic activity, reduces phosphorylated PI3K levels, and suppresses downstream EGFR-AKT signaling. EGFR-IN-196 increases intracellular ROS generation, induces mitochondrial depolarisation, and induces apoptosis in cancer cells. EGFR-IN-196 can be used for the research of lung cancer.
For research use only. We do not sell to patients.
- Formula: C18H11F2N5O
- Molecular Weight:351.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
EGFR-IN-196 (Compound 6E) inhibits purified EGFR kinase with an IC50 of 105.96 ± 0.45 nM[1].
EGFR-IN-196 (1-25 μM; 24 h) inhibits A549 lung cancer cell proliferation with an IC50 of 4.355 ± 0.028 μM and is non-toxic to HEK293 normal cells at 25 μM for 24 h[1].
EGFR-IN-196 (5-30 min) time-dependently reduces phosphorylated PI3K levels in viable A549 lung cancer cells, inhibiting downstream EGFR signaling[1].
EGFR-IN-196 (4.355 μM; 24 h) increases intracellular ROS levels and disrupts mitochondrial membrane potential in A549 lung cancer cells[1].
EGFR-IN-196 (4.355 μM; 24 h) induces apoptosis in A549 lung cancer cells, with 19.6% early and 13.1% late apoptotic cells observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 lung cancer cells
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Concentration:4.355 μM
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Incubation Time:24 h
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Result:Induced apoptotic cell death in A549 cells, with 19.6% early apoptotic cells and 13.1% late apoptotic cells detected by flow cytometry.
Chemical Information
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Molecular Weight 351.31
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Formula C18H11F2N5O
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SMILES
O=C(N)C1=NC(C2=CC=C(F)C=C2)=NC3=C1N=CN3C4=CC=C(F)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-196 Related Classifications
HY-181479 Related Classifications
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