1. Protein Tyrosine Kinase/RTK
  2. Src
  3. EPQpYEEIPIYL

EPQpYEEIPIYL 

Cat. No.: HY-P3279
Handling Instructions

EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

EPQpYEEIPIYL Chemical Structure

EPQpYEEIPIYL Chemical Structure

CAS No. : 147612-86-0

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Description

EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].

In Vitro

The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1473.52

Formula

C₆₆H₉₇N₁₂O₂₄P

CAS No.
Sequence Shortening

EPQpYEEIPIYL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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EPQpYEEIPIYL
Cat. No.:
HY-P3279
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