CBS-3595
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 908380-97-2
- Fòrmula: C18H17FN4O2S
- Peso molecular:372.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
213 μM
Compound: 1; CBS-3595
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Inhibition of human ERG expressed in HEK293 cells by patch clamp method
Inhibition of human ERG expressed in HEK293 cells by patch clamp method
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[PMID: 28613871] |
Chemical Information
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No. CAS 908380-97-2
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Peso molecular 372.42
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Fòrmula C18H17FN4O2S
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SMILES
CC(NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=C(S(C)=O)N2C)=C1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBS-3595 Related Classifications
HY-111164 Related Classifications
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