HDAC-IN-76
HDAC-IN-76 (compound 6i) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-76 IC50 values of 30 nM and 98 nM for Pf3D7 (chloroquine (HY-17589A) drug-susceptible strain) and PfDd2 (chloroquine (HY-17589A) drug-resistant strain), has a highly potent antimalarial activity against asexual blood-stage Plasmodium, respectively, and exhibits selective inhibition against parasites, with IC50 values of 7 nM and 9 nM for human HDAC1 and HDAC6, respectively, while inhibiting PfHDAC1.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C27H26N4O4
- Peso molecular:470.52
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
hHDAC1 7 nM (IC50) |
hHDAC6 9 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
136 μM
Compound: 6i
|
Cytotoxicity against HEK293 cells incubated for 24 hrs by Neutral Red Uptake assay
Cytotoxicity against HEK293 cells incubated for 24 hrs by Neutral Red Uptake assay
|
[PMID: 39208744] |
HDAC-IN-76 has low toxicity to HEK293 cells[1].
HDAC-IN-76 (1 μM) effectively inhibits PfHDAC1 with an inhibition rate of 70.2%[1].
HDAC-IN-76 has low activity against liver-stage parasites (IC50 PbEEF (Extraerythrocytic liver stage of Plasmodium berghei)=0.25 μM), good microsomal stability (t1/2 > 60 min), and low toxicity in HEK293 cells (IC50=136 μM, selectivity index SI=544)[1].
HDAC-IN-76 can effectively enter HepG2 cells and inhibit HDAC activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HEK293
-
Concentration:1%
-
Incubation Time:24 h
-
Result:Had low cytotoxicity to HEK293 cells.
Chemical Information
-
Peso molecular 470.52
-
Fòrmula C27H26N4O4
-
SMILES
O=C(CN(C(C1=CN(C)C2=C1C=CC=C2)=O)CC3=CC=C(C(NO)=O)C=C3)NCC4=CC=CC=C4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-76 Related Classifications
HY-161984 Related Classifications
Powered by Bioz