HZD37-5
HZD37-5 is a humanized monoclonal antibody specifically recognizing N78 loci of IL-17A. HZD37-5 binds to human and rhesus monkeys, blocks IL-17 induced signal transduction and the release of IL-6, IL-8, CXCL-1 and GM-GSF. HZD37-5 significantly inhibited human IL-17A induced-keratinocyte chemoattractant secretion. HZD37-5 can be used for the research of autoimmune diseases including psoriasis and psoriatic arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Species Reactivity
Human
IC50 & Target
[1]|
IL-17A |
IL-6 |
IL-8 |
In Vitro
HZD37-5 (0.16-20 nM) exhibits very high affinity for both human and rhesus monkey IL-17A, with Kd values of 7.4 ± 0.6 pM and 5.1 pM respectively[1].
HZD37-5 (4 μg/mL, 24 h) potently inhibits human IL-17A-induced signal transduction in HEK Blue IL-17 cells[1].
HZD37-5 (0.1-10000 nM; 24 h) potently inhibits human IL-17A-induced release of the pro-inflammatory mediators IL-6, IL-8, CXCL-1, and GM-CSF in HFF-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HFF-1 cells
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Concentration:0.1-10000 nM
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Incubation Time:24 h
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Result:Reduced IL-6, IL-8, CXCL-1, and GM-CSF levels.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6-8 weeks old)[1]
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Dosage:0.1 mg/kg; 1.0 mg/kg; 10.0 mg/kg
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Administration:Orbital venous plexus injection; single dose
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Result:Inhibited human IL-17A-induced KC secretion in a dose-dependent manner.
Exhibited statistically significant inhibition at P < 0.01 compared to IL-17A-only controls at 0.1, 1 and 10 mg/kg.
Gene ID
Accession
Target
CTLA-8/IL-17a
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Aplicación
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[HZD37-5]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HZD37-5 Related Classifications
HY-P992045 Related Classifications
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