NEPP11
NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion.
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- No. CAS: 313051-12-6
- Fòrmula: C26H36O3
- Peso molecular:396.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
ERK1 |
ERK2 |
MEK1 |
MEK2 |
C-Raf |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | Inhibition |
50 %
Compound: 1, NEPP11
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Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
Inhibition of manganese ion-induced apoptosis in PC12 cells assessesed as suppression of DNA fragmentation at 10 uM
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[PMID: 17706424] |
Chemical Information
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No. CAS 313051-12-6
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Peso molecular 396.57
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Fòrmula C26H36O3
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SMILES
C(CCCCCC1=CC=C(C)C=C1)[C@H]2/C(=C\CCCCCC(OC)=O)/C(=O)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NEPP11 Related Classifications
HY-180327 Related Classifications
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