2. Anti-infection
  3. Antibiotic Bacterial
  4. Flucloxacillin

Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Flucloxacillin

Flucloxacillin Chemical Structure

CAS No. : 5250-39-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Flucloxacillin:

Flucloxacillin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Flucloxacillin

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].

Cellular Effect
Cell Line Type Value Description References
Sf21 IC50
208.6 μM
Compound: Flucloxacillin
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
Sf21 IC50
429.1 μM
Compound: Flucloxacillin
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
In Vivo

Flucloxacillin (200 mg/kg; i.p.; three times/day, for 21 days; male Wistar rats) has effective against the most common bacterial strains in periprosthetic infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; three times/day, for 21 days
Result: Reducted germs in the biofilm and in the bone tissue.
Clinical Trial
Molecular Weight

453.87

Formula

C19H17ClFN3O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(F)C=CC=C4Cl)=O)N1C2=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2033 mL 11.0164 mL 22.0327 mL
5 mM 0.4407 mL 2.2033 mL 4.4065 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2033 mL 11.0164 mL 22.0327 mL 55.0819 mL
5 mM 0.4407 mL 2.2033 mL 4.4065 mL 11.0164 mL
10 mM 0.2203 mL 1.1016 mL 2.2033 mL 5.5082 mL
15 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6721 mL
20 mM 0.1102 mL 0.5508 mL 1.1016 mL 2.7541 mL
25 mM 0.0881 mL 0.4407 mL 0.8813 mL 2.2033 mL
30 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
40 mM 0.0551 mL 0.2754 mL 0.5508 mL 1.3770 mL
50 mM 0.0441 mL 0.2203 mL 0.4407 mL 1.1016 mL
60 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
80 mM 0.0275 mL 0.1377 mL 0.2754 mL 0.6885 mL
100 mM 0.0220 mL 0.1102 mL 0.2203 mL 0.5508 mL
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Flucloxacillin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flucloxacillin5250-39-5AntibioticBacterialantibioticgram-positive bacteriagram-negative bacteriaInhibitorinhibitorinhibit

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