AMX-883
AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 3102636-19-8
- Formula: C45H58FN5O5
- Molecular Weight:767.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
BRD9 |
In Vitro
Combination of AMX-883 with Venetoclax (HY-15531) resulted in synergistic efficacy in MV4-11 and MOLM-13 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3102636-19-8
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Molecular Weight 767.97
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Formula C45H58FN5O5
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SMILES
COC(C=C(C(C(C)=C1C)=CN(C)C1=O)C=C2OC)=C2CN(CC3)CC4(CC4)N3CC5=C6C([C@H](N(CC6)C(/C(C#N)=C/C(C)(C)CF)=O)C(C)C)=CC(OC)=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMX-883 Related Classifications
HY-182766 Related Classifications
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