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Cat. No.: HY-B0925A

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Oxacillin

Name: Oxacillin
Brand: MedChemExpress
SKU: HY-B0925A
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2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.

For research use only. We do not sell to patients.

CAS No.: 66-79-5
Formula: C₁₉H₁₉N₃O₅S
Molecular Weight:401.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Oxacillin Chemical Structure

CAS No.: 66-79-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens^[1].

IC₅₀ & Target

β-lactam

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	35 μM Compound: Oxacillin	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins	[PMID: 23344796]

In Vitro

Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively^[1].
The Oxacillin-resistant strains are highly resistant to other penicillins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD₅₀) of 253.3 mg/kg in mice infected with Staphylococcus aureus Evans. The oral CD₅₀ of Oxacillin is 187.2 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 strain male albino mice infected with S. aureus Evans^[2]
Dosage:

50, 100, 200, 400 and 800 mg/kg
Administration:

Subcutaneous injection, once
Result:

Showed therapeutic activity with CD₅₀ of 253.3 mg/kg.

Related Protocols :

Chemical Information

CAS No. 66-79-5
Molecular Weight 401.44
Formula C₁₉H₁₉N₃O₅S
SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=CC=CC=C4)=O)N1C2=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Microorganisms

The Staphylococcus aureus ArlS Kinase Inhibitor Tilmicosin Has Potent Anti-Biofilm Activity in Both Static and Flow Conditions. [Abstract]

2024 Jan 25;12(2):256. PMID: 38399660
Curr Microbiol

Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes. [Abstract]

2023 May 31;80(7):230. PMID: 37256372

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. KIRBY WM, et al. Oxacillin: laboratory and clinical evaluation. JAMA. 1962 Sep 1;181:739-44. [Content Brief]

[2]. Yurchenco JA, et al. Nafcillin and oxacillin: comparative antistaphylococcal activity in mice. J Antibiot (Tokyo). 1976 Apr;29(4):460-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Oxacillin

Publications Citing Use of MedChemExpress (MCE) Oxacillin

All Antibiotic Isoforms