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Cat. No.: HY-106371

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Siccanin

Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC₅₀=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi.

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CAS No.: 22733-60-4
Formule: C₂₂H₃₀O₃
Masse moléculaire:342.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Siccanin Chemical Structure

CAS No.: 22733-60-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC₅₀=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi^[1].

IC₅₀ & Target

Succinate Dehydrogenase Inhibitor

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In Vitro

Siccanin (10 μg/mL) is species-selective, and Siccanin inhibits bacterial SDH from P. aeruginosa and P. putida but not SDH from E. coli, and C. glutamicum; Siccanin inhibits rodent SDH but not porcine SDH^[1].
Specifically, Siccanin inhibits SDH from P. aeruginosa (residual activity 13%) and P. putida (>1%) membranes, and of mouse (>7%) and rat (19%) liver mitochondria, but not SDH from E. coli (77%) and C. glutamicum (97%) membranes and of porcine heart mitochondria (106%)^[1].
Siccanin (3 μg/mL) competely inhibits the growth of Trichophyton mentagrophytes (IC₅₀=0.3 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 22733-60-4
Masse moléculaire 342.47
Formule C₂₂H₃₀O₃
SMILES

C[C@@]12[C@@]3([H])[C@@]4(CO[C@@]3([H])C5=C(O)C=C(C)C=C5O2)[C@@](C(C)(CCC4)C)([H])CC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mogi T, et al. Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. J Biochem. 2009 Sep;146(3):383-7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Siccanin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Siccanin Related Classifications

HY-106371 Related Classifications