Fradafiban hydrochloride  (Synonyms: BIBU-52 hydrochloride)

Fradafiban (BIBU-52) hydrochloride is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a K_d value of 148 nM.

Kd: 148 nM (human platelet GP IIb/IIIa complex)^[1]

Fradafiban hydrochloride is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban hydrochloride binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban hydrochloride reversibly binds to the human platelet GP IIb/IIIa complex with a K_d value of 148 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fradafiban hydrochloride has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

403.86

C₂₀H₂₂ClN₃O₄

Solid

White to off-white

O=C(O)C[C@H]1C(N[C@H](COC2=CC=C(C3=CC=C(C(N)=N)C=C3)C=C2)C1)=O.[H]Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.  [Content Brief]