3-TYP (Standard)
3-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 120241-79-4
- Fòrmula: C7H6N4
- Peso molecular:146.15
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Targets: Sirtuin (SIRT) 3, Methionine Adenosyltransferase (MAT) 2, Indoleamine 2,3-Dioxygenase (IDO)[3]
IC50: ~38 μM (SIRT3)[3]
Chemical Information
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No. CAS 120241-79-4
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Peso molecular 146.15
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Fòrmula C7H6N4
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SMILES
C1(C2=CN=NN2)=CC=CN=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Pi H, et al. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015;11(7):1037-51. [Content Brief]
[2]. Zhai M, et al. Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis. J Pineal Res. 2017 Sep;63(2). [Content Brief]
[3]. Galli U, et al. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-TYP (Standard) Related Classifications
HY-108331R Related Classifications
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