Cyromazine
Based on 1 Customer Validation
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats.
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- Pureza: 99.79%
- No. CAS: 66215-27-8
- Fòrmula: C6H10N6
- Peso molecular:166.18
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
Cyromazine (169.35 mg/kg, oral gavage for 28 consecutive days) combined with Chlorpyrifos (HY-B0815) treated rats show huddling, mild tremor and diarrhea few minutes after dosing, but no manifestation is observed following aqueous green tea (GT) extract supplementation[3].
Cyromazine (169.35 mg/kg, oral gavage for 28 consecutive days) combined with Chlorpyrifos (HY-B0815) treated rats ameliorates the loss of body weight and the increase of relative kidney after the administration of aqueous green tea (GT) extract[3].
Cyromazine (50 PPM, feed on a diet for 7 days) on the inhibition effect of primordial germ cells (PGCs) is through the Ecdysone (HY-N0179) signaling pathway in the germ cells of larval ovaries[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 66215-27-8
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Appearance Solid
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Peso molecular 166.18
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Fòrmula C6H10N6
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Color White to off-white
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SMILES
NC1=NC(N)=NC(NC2CC2)=N1
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Synonyms
Cyromazin; CGA-72662
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 200 mg/mL (1203.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (30.09 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (30.09 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Levot GW, et al. Survival advantage of cyromazine-resistant sheep blowfly larvae on dicyclanil- and cyromazine-treated Merinos. Aust Vet J. 2014 Nov;92(11):421-6. [Content Brief]
[2]. Khalid MZ, et al. Cyromazine Effects the Reproduction of Drosophila by Decreasing the Number of Germ Cells in the Female Adult Ovary[J]. Insects. 2022 Apr 27;13(5):414. [Content Brief]
[4]. Khalid MZ, et al. Cyromazine affects the ovarian germ cells of Drosophila via the ecdysone signaling pathway[J]. Front Physiol. 2022 Sep 29;13:992306. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0176 mL | 30.0879 mL | 60.1757 mL | 150.4393 mL |
| 5 mM | 1.2035 mL | 6.0176 mL | 12.0351 mL | 30.0879 mL | |
| 10 mM | 0.6018 mL | 3.0088 mL | 6.0176 mL | 15.0439 mL | |
| 15 mM | 0.4012 mL | 2.0059 mL | 4.0117 mL | 10.0293 mL | |
| 20 mM | 0.3009 mL | 1.5044 mL | 3.0088 mL | 7.5220 mL | |
| 25 mM | 0.2407 mL | 1.2035 mL | 2.4070 mL | 6.0176 mL | |
| 30 mM | 0.2006 mL | 1.0029 mL | 2.0059 mL | 5.0146 mL | |
| 40 mM | 0.1504 mL | 0.7522 mL | 1.5044 mL | 3.7610 mL | |
| 50 mM | 0.1204 mL | 0.6018 mL | 1.2035 mL | 3.0088 mL | |
| 60 mM | 0.1003 mL | 0.5015 mL | 1.0029 mL | 2.5073 mL | |
| 80 mM | 0.0752 mL | 0.3761 mL | 0.7522 mL | 1.8805 mL | |
| 100 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5044 mL |
Cyromazine Related Classifications
HY-B1331 Related Classifications
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