SGC3027
Based on 6 publication(s) in Google Scholar
SGC3027 is a histone methyltransferase inhibitor. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.06%
- No. CAS: 2624313-13-7
- Fòrmula: C41H47ClN6O6S
- Peso molecular:787.37
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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Chemical Probe Library
HY-L063
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Anti-Blood Cancer Compound Library
HY-L079
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Targeted Diversity Library
HY-L099
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Epigenetics Compound Library Mini
HY-L005M
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) SGC3027
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Customer Validation & Images
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WB
Ver todos los productos específicos de isoformas Histone Methyltransferase
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Actividad biológica
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PRMT7 |
SGC3027 is a pro-drug of SGC8158 which releases the active component upon reduction in the cell by reductases.? In cellular assays using C2C12 cells, SGC3027 inhibits the methylation of HSP70 with IC50=1.3 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2624313-13-7
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Appearance Solid
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Peso molecular 787.37
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Fòrmula C41H47ClN6O6S
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Color Light yellow to yellow
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SMILES
ClC1=CC=C(C2=CC(CN(C(CC(C)(C)C3=C(C)C(C(C)=C(C)C3=O)=O)=O)CCCCSC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C(N=CN=C6N)=C6N=C5)O4)=CC=C2)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
Nat Commun
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth. [Abstract]2021 Mar 29;12(1):1946. PMID: 33782401
SGC3027 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Mar 29;12(1):1946. [Abstract]
EZM2302 (10 μM), GSK591 (10 μM), or SGC3027 (10 μM) treatment alone for 24 h changed alternative splicing events commonly regulated by PRMT4, 5, and 7, and their co-treatment exhibited more drastic effects in all three cell lines, namely MCF7, HCT 116, and LNCaP.
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Mol Cell
2021 Aug 5;81(15):3171-3186.e8. PMID: 34171297 -
Mol Biomed
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression. [Abstract]2025 Dec 22;6(1):148. PMID: 41428171 -
Cell Death Dis
2026 Mar 24;17(1):363. PMID: 41876450 -
Exp Cell Res
2023 Jun 1;427(1):113586. PMID: 37030331
Solvente y solubilidad
DMSO : 250 mg/mL (317.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (2.64 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.2701 mL | 6.3503 mL | 12.7005 mL | 31.7513 mL |
| 5 mM | 0.2540 mL | 1.2701 mL | 2.5401 mL | 6.3503 mL | |
| 10 mM | 0.1270 mL | 0.6350 mL | 1.2701 mL | 3.1751 mL | |
| 15 mM | 0.0847 mL | 0.4234 mL | 0.8467 mL | 2.1168 mL | |
| 20 mM | 0.0635 mL | 0.3175 mL | 0.6350 mL | 1.5876 mL | |
| 25 mM | 0.0508 mL | 0.2540 mL | 0.5080 mL | 1.2701 mL | |
| 30 mM | 0.0423 mL | 0.2117 mL | 0.4234 mL | 1.0584 mL | |
| 40 mM | 0.0318 mL | 0.1588 mL | 0.3175 mL | 0.7938 mL | |
| 50 mM | 0.0254 mL | 0.1270 mL | 0.2540 mL | 0.6350 mL | |
| 60 mM | 0.0212 mL | 0.1058 mL | 0.2117 mL | 0.5292 mL | |
| 80 mM | 0.0159 mL | 0.0794 mL | 0.1588 mL | 0.3969 mL | |
| 100 mM | 0.0127 mL | 0.0635 mL | 0.1270 mL | 0.3175 mL |
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