Amorphigenin
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.
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- No. CAS: 4208-09-7
- Fòrmula: C23H22O7
- Peso molecular:410.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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c-Fos |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
0.05 μg/mL
Compound: 5
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 8326318] |
| HCT-8 | ED50 |
0.03 μg/mL
Compound: 5
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Cytotoxicity against human HCT8 cells
Cytotoxicity against human HCT8 cells
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[PMID: 8326318] |
| KB | ED50 |
0.04 μg/mL
Compound: 5
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 8326318] |
| LNCaP | ED50 |
0.3 μM
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 32459967] |
| LNCaP | ED50 |
7.9 μg/mL
Compound: 7
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 17125241] |
| Lu1 | ED50 |
4.8 μg/mL
Compound: 7
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Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
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[PMID: 17125241] |
| MCF7 | ED50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 17125241] |
| P388 | ED50 |
0.04 μg/mL
Compound: 5
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 8326318] |
| RPMI-7951 | ED50 |
0.05 μg/mL
Compound: 5
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Cytotoxicity against human RPMI7951 cells
Cytotoxicity against human RPMI7951 cells
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[PMID: 8326318] |
| TE-671 | ED50 |
<0.01 μg/mL
Compound: 5
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Cytotoxicity against human TE671 cells
Cytotoxicity against human TE671 cells
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[PMID: 8326318] |
Chemical Information
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No. CAS 4208-09-7
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Peso molecular 410.42
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Fòrmula C23H22O7
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SMILES
O=C1[C@@]2([C@]([H])(OC3=C1C=CC4=C3C[C@@H](O4)C(CO)=C)COC5=C2C=C(C(OC)=C5)OC)[H]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Lee KW, et al. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner. Curr Issues Mol Biol. 2022 Jun 29;44(7):2856-2867. [Content Brief]
[2]. Kim BG, et al. Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells. Anat Cell Biol. 2010 Dec;43(4):310-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amorphigenin Related Classifications
HY-116640 Related Classifications
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