Anthramycin
Anthramycin, a member of the pyrolobenzodiazepine (PBD) family, is a potent antibiotic. Anthramycin has potent antitumor activity. Anthramycin can act as an potent antagonist of cholecystokinin in the central nervous system in mice.
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- No. CAS: 4803-27-4
- Fòrmula: C16H17N3O4
- Peso molecular:315.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
ANT is delivered through the skin for PG (propylene glycol), TC (Transcutol P) and PGML (propylene glycol monolaurate) with the active “tracking” the skin penetration of both PG and TC[1].
Anthramycin (10-1000 μM) dose not affect the ATPase activity of heart mitochondria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anthramycin (0.1-0.5 mg/kg, SC, daily for 8 days) has no effect on mitochondrial metabolism of the rat heart[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ddY mice (20 ± 2 g, 12-14 each group)[2]
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Dosage:0, 0.3, and 0.5 mg/kg
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Administration:IP, once, 10 min before the intracisternal (i.c.) injection of CCK
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Result:Significantly inhibited CCK-induced increase in the pain threshold in a dose-dependent manner. Almost completely suppressed the antinociceptive effects of CCK at the higher dose (0.5 mg/kg).
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Animal Model:Female CFN Gif rats (140-180 g)[3]
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Dosage:0.1 mg/kg, 0.25 mg/kg, and 0.5 mg/kg
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Administration:SC, daily for 8 days
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Result:Recorded no differences between anthramycin- and DMSO-treated rats with respect to P/O ratios, respiration rates, and ATPase activity of heart mitochondria.
Chemical Information
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No. CAS 4803-27-4
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Peso molecular 315.32
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Fòrmula C16H17N3O4
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SMILES
O=C1N2[C@@]([C@H](NC3=C(O)C(C)=CC=C31)O)([H])CC(/C=C/C(N)=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Haque T, et al. Topical delivery of anthramycin II. Influence of binary and ternary solvent systems. Eur J Pharm Sci. 2018 Aug 30;121:59-64. [Content Brief]
[2]. Kubota K, et al. Cholecystokinin antagonism by anthramycin, a benzodiazepine antibiotic, in the central nervous system in mice. Brain Res. 1989 Apr 17;485(1):62-6. [Content Brief]
[3]. Cargill C, et al. Effects of daunomycin and anthramycin on electrocardiogram and mitochondrial metabolism of the rat heart. J Natl Cancer Inst. 1974 Aug;53(2):481-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anthramycin Related Classifications
HY-150036 Related Classifications
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