Aritinercept
Based on 1 Customer Validation
Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus.
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- Pureza : 99.9%
- No. CAS: 3057276-00-0
- Peso molecular:61.925 kDa
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Almacenamiento:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
Species Reactivity
Human
IC50 & Target
[1]|
IL-17A |
In Vitro
Aritinercept exhibits high binding affinity (Kd) to human BAFF (117 pM), human APRIL (25 pM), mouse BAFF (31 pM), and mouse APRIL (505 pM) in a cell-free surface plasmon resonance binding assay[1].
Aritinercept potently inhibits human APRIL (IC50 = 0.002 nM), mouse BAFF (IC50 = 1.5 nM), and mouse APRIL (IC50 = 2.7 nM) in a cell-free competitive ELISA, with no detectable inhibition of human BAFF[1].
Aritinercept reduces BAFF and APRIL-costimulated proliferation of human primary B cells and mouse splenocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Aritinercept (1 mg/kg; s.c.; single dose) suppresses peripheral B cells, and (5-80 mg/kg; s.c.; weekly; 4 weeks) induces sustained reductions in all serum immunoglobulins in healthy cynomolgus monkeys[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NZBxNZW F1 (randomized by body weight and proteinuria scores)[1]
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Dosage:1 mg/kg; 3 mg/kg; 10 mg/kg
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Administration:s.c.; weekly; 6 weeks
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Result:Significantly improved survival at all doses tested.
Reduced proteinuria.
Decreased histological markers of renal damage.
Significantly decreased serum IFNγ and IL-17A levels at all doses.
Dose-dependently reduced serum anti-dsDNA autoantibodies.
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Animal Model:Cynomolgus monkeys[1]
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Dosage:1 mg/kg; 5 mg/kg; 20 mg/kg; 80 mg/kg
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Administration:s.c.; single dose (1 mg/kg); weekly; 4 weeks (5, 20, 80 mg/kg)
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Result:Suppressed peripheral B cells (single 1 mg/kg subcutaneous dose).
Induced sustained reductions in all serum immunoglobulins (weekly subcutaneous doses of 5, 20, or 80 mg/kg for 4 weeks).
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- How to Choose the Right Model Animal
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Gene ID
Accession
Target
TNFSF13B/BAFF/CD257
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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FPIA_[PROTEIN]2-FC
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Aritinercept. The ED50 for this effect is 0.5949 ng/mL.
Chemical Information
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No. CAS 3057276-00-0
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Appearance Liquid
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Peso molecular 61.925 kDa
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Color Colorless to light yellow
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SMILES
[Aritinercept]
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Synonyms
AUR-200
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aritinercept Related Classifications
HY-P992101 Related Classifications
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Keywords
- Aritinercept
- 3057276-00-0
- AUR-200
- AUR200
- AUR 200
- TNF Receptor
- IFNAR
- Interleukin Related
- Tumor Necrosis Factor Receptor
- TNFR
- Interferon-α/β receptor
- Interferon-alpha/beta receptor
- IL
- IFNγ
- IL-17A
- systemic lupus erythematosus
- renal damage markers
- anti-dsDNA autoantibodies
- B cell proliferation
- serum immunoglobulins
- peripheral B cells
- BAFF
- APRIL
- Inhibitor
- inhibitor
- inhibit