Asukamycin
Based on 1 Customer Validation
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines.
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- Pureza: 95.0%
- No. CAS: 61116-33-4
- Fòrmula: C31H34N2O7
- Peso molecular:546.61
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC38 | EC50 |
4.5 μM
Compound: Asukamycin
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Antiproliferative activity against human HCC38 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human HCC38 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
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[PMID: 37984298] |
| MDA-MB-231 | EC50 |
13.8 μM
Compound: Asukamycin
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
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[PMID: 37984298] |
In Vitro
Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC50 of 1-5 μM[1].
Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity[1].
Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human myeloid THP-1, HL-60, U-118 MG, U-87 MG and U-937 cells
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Concentration:1-50 μM
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Incubation Time:24 hours
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Result:Reduced viability of five different cell lines in a concentration-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[2]
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Dosage:0-450 mg/kg
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Administration:Intraperitoneal injection
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Result:Had no effect on mice when administered by 450 mg/kg and the acute toxicity (LD50) was 48.5 mg/kg by intraperitoneal injection.
Chemical Information
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No. CAS 61116-33-4
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Appearance Solid
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Peso molecular 546.61
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Fòrmula C31H34N2O7
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Color Light yellow to yellow
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SMILES
O=C1[C@@H]2[C@H]([C@@](O)(C=C1NC(/C=C/C=C/C=C/C3CCCCC3)=O)/C=C/C=C/C=C/C(NC4=C(CCC4=O)O)=O)O2
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Structure Classification
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Initial Source
Streptomyces nodosus subsp. asukaensis.
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Shipley PR, et, al. Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Int J Mol Med. 2009 Nov;24(5):711-5. [Content Brief]
[2]. Omura S, et, al. A new antibiotic,, asukamycin, produced by Streptomyces. J Antibiot (Tokyo). 1976 Sep;29(9):876-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asukamycin Related Classifications
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