BT-O2C
Based on 1 Customer Validation
BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C can be used for research on cancer.
(Pink: p300 ligand (HY-174868); Blue: Cereblon ligand (HY-W023573); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.31%
- No. CAS: 3055107-34-8
- Fòrmula: C48H48F5N9O8
- Peso molecular:973.94
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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Actividad biológica
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p300 |
Cereblon |
BT-O2C (0.1-10 μM, 24 h) can significantly degrade p300 and has almost no effect on the degradation of CBP in HAPI cells[1].
BT-O2C (0.25-4 μM, 48-72 h) exhibits significant cytotoxicity in NCC-CDS1-X1 (IC50 = 152 nM) and KITRA (IC50 = 221 nM) cells[1].
BT-O2C (4 μM, 6 h) significantly reduces the expression of CDS target genes in NCC-CDS-X1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HAPI cells
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Concentration:0.1, 1 and 10 μM
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Incubation Time:24 h
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Result:Selectively degraded the protein level of p300, superior to JQAD1 (HY-145765).
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Cell Line:NCC-CDS-X1 cells
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Concentration:4 μM
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Incubation Time:6 h
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Result:Significantly reduced the expression of ETV1, ETV4, ETV5, CCNEE1 and MYC.
Chemical Information
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No. CAS 3055107-34-8
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Appearance Solid
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Peso molecular 973.94
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Fòrmula C48H48F5N9O8
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Color Light yellow to yellow
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SMILES
O=C(N(CC1=CC=C(F)C=C1)[C@@H](C)C(F)(F)F)CN(C(N[C@]23C[C@@H](F)C4=C3C=CC(C5=CN(CC(NCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)N=C5)=C4)=O)C2=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BT-O2C Related Classifications
HY-174866 Related Classifications
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