cis-ACCP
Based on 1 Customer Validation
cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.
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- Pureza: 97.0%
- No. CAS: 777075-44-2
- Fòrmula: C7H15N2O4P
- Peso molecular:222.18
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
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MMP-2 4 μM (IC50) |
MMP-9 20 μM (IC50) |
cis-ACCP (oral, i.v.,i.p.; 50, 150 mg/kg) only has distribution in the extracellular fluid[1].
Pharmacokinetic Parameters of cis-ACCP in rats[1].
| PK parameter | iv | PO | ip |
| AUC (min • µg/mL) | 7637 | 79 | 2677 |
| T1/2 (min) | 18.8 | 126 | 108 |
| Cmax(ng/mL) | 306000 | 712 | 144000 |
| CL (mL/min/kg) | 6.9 | - | - |
| Tmax(min) | - | 17.4 | 0.5 |
| Vss(mL/Kg) | 186 | - | - |
| F (%) | - | 0.35 | 11.8 |
| Fu (%) | 83.9 | 2.2 | 48 |
| Ttime over MIC (hr) | >4 | >6 | 24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL mice[1]
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Dosage:50, 250, 500 mg/kg; 12.5 to 50 mg/kg
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Administration:Oral, intraperitoneal, daily for two weeks; daily, 21 days
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Result:Showed no toxic effects and showed 50-85% inhibition of metastasis formation, depending on the dose.
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Animal Model:Rats[1]
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Dosage:50, 150 mg/kg
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Administration:Oral, intravenous, intraperitoneal
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Result:Showed 84% of the intravenously administered drug are excreted unchanged.
Chemical Information
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No. CAS 777075-44-2
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Appearance Solid
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Peso molecular 222.18
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Fòrmula C7H15N2O4P
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Color White to off-white
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SMILES
OP(O)(C(N[C@H]1[C@@H](N)CCCC1)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
H2O : 25 mg/mL (112.52 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Español - ES (251 KB)
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- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Hoffman, Amnon et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis. Journal of medicinal chemistry vol. 51,5 (2008): 1406-14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5009 mL | 22.5043 mL | 45.0086 mL | 112.5214 mL |
| 5 mM | 0.9002 mL | 4.5009 mL | 9.0017 mL | 22.5043 mL | |
| 10 mM | 0.4501 mL | 2.2504 mL | 4.5009 mL | 11.2521 mL | |
| 15 mM | 0.3001 mL | 1.5003 mL | 3.0006 mL | 7.5014 mL | |
| 20 mM | 0.2250 mL | 1.1252 mL | 2.2504 mL | 5.6261 mL | |
| 25 mM | 0.1800 mL | 0.9002 mL | 1.8003 mL | 4.5009 mL | |
| 30 mM | 0.1500 mL | 0.7501 mL | 1.5003 mL | 3.7507 mL | |
| 40 mM | 0.1125 mL | 0.5626 mL | 1.1252 mL | 2.8130 mL | |
| 50 mM | 0.0900 mL | 0.4501 mL | 0.9002 mL | 2.2504 mL | |
| 60 mM | 0.0750 mL | 0.3751 mL | 0.7501 mL | 1.8754 mL | |
| 80 mM | 0.0563 mL | 0.2813 mL | 0.5626 mL | 1.4065 mL | |
| 100 mM | 0.0450 mL | 0.2250 mL | 0.4501 mL | 1.1252 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
cis-ACCP Related Classifications
HY-131417 Related Classifications
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