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Referencia número: HY-122746

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E67-2

E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC₅₀ value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase.

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No. CAS: 1364914-62-4
Fòrmula: C₂₁H₃₆N₆O₂
Peso molecular:404.55

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

E67-2 Chemical Structure

No. CAS: 1364914-62-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC50: 3.4 μM (H3K9 Jumonji demethylase)^[1]

Ver todos los productos específicos de isoformas Histone Methyltransferase :

In Vitro

E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC₅₀ of 75 µM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1364914-62-4
Peso molecular 404.55
Fòrmula C₂₁H₃₆N₆O₂
SMILES

CN(C)C1=C2C=C(OC)C(OCCCCCN)=CC2=NC(NCCCN(C)C)=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Upadhyay AK, et al. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol. 2012;416(3):319-327. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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- In Vitro
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E67-2

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

E67-2 Related Classifications

HY-122746 Related Classifications