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Referencia número: HY-135876

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γ-Elemene

Name: γ-Elemene
Brand: MedChemExpress
SKU: HY-135876
Availability: PreOrder

(Synonyms: (-)-γ-Elemene)

γ-Elemene ((-)-γ-Elemene) is a lipid-lowering agent. γ-Elemene increases superoxide dismutase (SOD). γ-Elemene reduces the expression of adhesion molecules (VCAM-1, ICAM-1) in cells damaged by H₂O₂. γ-Elemene regulates lipid peroxidation. γ-Elemene protects cells from peroxidative damage induced by high fat and H₂O₂. γ-Elemene decreases lipid content. γ-Elemene can be used in the research of atherosclerosis.

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No. CAS: 29873-99-2
Fòrmula: C₁₅H₂₄
Peso molecular:204.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

γ-Elemene Chemical Structure

No. CAS: 29873-99-2

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Actividad biológica

Descripciòn

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In Vitro

Oxidative StressLocal Vascular RegulationLipid Metabolism

Oxidative Stress

γ-Elemene and (-)-γ-Elemene (1 μg/mL; 24 h) exert antioxidant protective effects against H₂O₂-induced oxidative damage in human umbilical vein endothelial cells (HUVEC). The increase rates of superoxide dismutase (SOD) induced by them are 23.75% and 22.45%, respectively, while the decrease rates of malondialdehyde (MDA) are 35.22% and 36.82%, respectively^[1].

Local Vascular Regulation

(-)-γ-Elemene (24 h) reduces the expression of adhesion factors in H₂O₂-injured HUVEC cells, with a reduction rate of 22.87% for VCAM-1 and 15.58% for ICAM-1^[1].

Lipid Metabolism

(-)-γ-Elemene (24 h) reduces intracellular lipid levels in free fatty acid (FFA)-loaded HepG2 cells, with a triglyceride (TG) reduction rate of 21.39% and a non-esterified fatty acid (NEFA) reduction rate of 16.43%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

human umbilical vein endothelial cells (HUVEC)
Concentration:

Not specified
Incubation Time:

24 h
Result:

Reduced ICAM-1 levels by 15.58%.
Reduced VCAM-1 levels by 22.87%.

Related Protocols :

Chemical Information

No. CAS 29873-99-2
Peso molecular 204.36
Fòrmula C₁₅H₂₄
SMILES

C(C)(=C)[C@@H]1[C@](C=C)(C)CCC(=C(C)C)C1
Synonyms

(-)-γ-Elemene
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shang, et al. Use of gamma-elemene and derivatives thereof in preventing atherosclerosis. CN103284979A. China. 2013-06-17.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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