HGS101
HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Human
CCR5/CD195
HGS101 (1 h) shows EC50 values of 0.001 μg/mL for Maraviroc (HY-13004)-sensitive, 0.0003 μg/mL for Maraviroc-resistant, and 0.00002 μg/mL for Maraviroc-resistant HIV-1 in the presence of Maraviroc in JC6 cells[1].
HGS101 (1 h) shows EC50 values of 0.03 μg/mL for Maraviroc-sensitive, 0.03 μg/mL for Maraviroc-resresistant, and 0.01 μg/mL for Maraviroc-resistant HIV-1 in the presence of Maraviroc in PBMCs[1].
HGS101 (0.3 µg/ mL, 1 h) restores Maraviroc inhibition (EC50 of 0.007 nM) of Maraviroc-resistant HIV-1 in PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Simian immunodeficiency virus-uninfected RMs models[2]
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Dosage:10 mg/kg
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Administration:Intravenous injection, every 15 days for 10 times
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Result:Did not reduce the levels of total or proliferating CD4+ and CD8+ T-cells in blood and tissues.
Reduced the levels of CCR5+ T-cells in blood and lymph nodes.
Induced a complex anatomic redistribution of CD25+ T-cell.
Induced specific changes in the transcriptional profile of leukocytes.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
N/A
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Latinovic O, et al. CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells. Virology. 2011 Mar 1;411(1):32-40. [Content Brief]
[2]. aaffe JE, et al. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol. 2012 Feb;41(1):24-42. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HGS101 Related Classifications
HY-P991541 Related Classifications
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