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Referencia número: HY-108546

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L-AP3

(Synonyms: 3-Phosphono-L-alanine)

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L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.91%
No. CAS: 23052-80-4
Fòrmula: C₃H₈NO₅P
Peso molecular:169.07

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

L-AP3 Chemical Structure

No. CAS: 23052-80-4

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Actividad biológica

Descripciòn

L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively^[1].

Ver todos los productos específicos de isoformas mGluR :

In Vitro

L-AP3 inhibits D-phosphoserine and L-phosphoserine with K_is of 151 μM and 845 μM, respectively^[1].
L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus^[1].
L-AP3 may have selectivity for Group II subtypes since it inhibits [³H]glutamate binding to mGlu3, receptors (K_i 125 μM)^[1].
L-AP3 is a potent inhibitor of sodium-dependent L-[³H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 23052-80-4
Appearance Solid
Peso molecular 169.07
Fòrmula C₃H₈NO₅P
Color White to off-white
SMILES

N[C@@H](CP(O)(O)=O)C(O)=O
Synonyms

3-Phosphono-L-alanine
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. J E Hawkinson, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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L-AP3

Ver todos los productos específicos de isoformas mGluR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

L-AP3 Related Classifications

HY-108546 Related Classifications