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Referencia número: HY-135079

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Lerimazoline

Lerimazoline is a selective 5-HT1D receptor agonist with K_i values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine.

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No. CAS: 54765-26-3
Fòrmula: C₁₃H₁₈N₂
Peso molecular:202.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Lerimazoline Chemical Structure

No. CAS: 54765-26-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

IC₅₀ & Target^[1]

5-HT_1D Receptor

72 nM (Ki)

5-HT_1B Receptor

3480 nM (Ki)

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In Vitro

Lerimazoline (Compound 29) (0.1-1 μM; 60 min) binds to human h5-HT₁B receptors with a K_i of 3480 nM^[1].
Lerimazoline (0.1-1 μM; 60 min) binds to human h5-HT₁D receptors with a K_i of 72 nM, displaying 48-fold selectivity for h5-HT₁D over h5-HT₁B receptors^[1].
Lerimazoline (1-10 μM; 30 min) inhibits Forskolin (HY-15371)-stimulated cAMP production in transfected CHO Pro 5 cells^[1].
Lerimazoline (10-10000 nM) induces contractions of rabbit saphenous vein with a 95% of the maximal effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 54765-26-3
Peso molecular 202.30
Fòrmula C₁₃H₁₈N₂
SMILES

CC1=C(CC2=NCCN2)C(C)=CC(C)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Law H, et al. Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation. J Med Chem. 1998 Jun 18;41(13):2243-51. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Lerimazoline

Ver todos los productos específicos de isoformas 5-HT Receptor

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Lerimazoline Related Classifications

HY-135079 Related Classifications