Moxalactam
Based on 1 publication(s) in Google Scholar
Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases.
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- No. CAS: 64952-97-2
- Fòrmula: C20H20N6O9S
- Peso molecular:520.47
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Almacenamiento:
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Publications Citing Use of MedChemExpress (MCE) Moxalactam
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Actividad biológica
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β-lactam |
Moxalactam (Latamoxef) inhibits 90% of strains of Escherichia coli, Klebsiella species, Proteus species, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and Salmonella species, including strains which are resistant to Cephalothin (HY-B1275A) and Gentamicin (HY-A0276A) at concentrations of less than 1 μg/mL[1].
Moxalactam exhibits moderate activity against P. aeruginosa and is usually active against other species of Pseudomonas, Acinetobacter species are usually resistant to Moxalactam[1].
Moxalactam has marked stability in vitro against a variety of β-lactamases, including that produced by B. fragilis, inhibits production of β-lactamases and does not induce class I β-lactamase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old male strain ICR mice, weighing 18-20 g, bacterial infection model[2]
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Dosage:0-7.4 mg/mouse
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Administration:Subcutaneous injection, once
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Result:Showed protective activity with ED50s less than 7.4 mg/mouse against gram-positive and gram-negative bacterial infected mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 64952-97-2
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Peso molecular 520.47
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Fòrmula C20H20N6O9S
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SMILES
O=C(C(N12)=C(CSC3=NN=NN3C)CO[C@]2([H])[C@](OC)(NC(C(C(O)=O)C4=CC=C(O)C=C4)=O)C1=O)O
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Synonyms
Latamoxef; Lamoxactam; LY-127935
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Moxalactam Related Classifications
HY-B1484A Related Classifications
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