Oxacillin
Based on 14 publication(s) in Google Scholar
Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.
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- No. CAS: 66-79-5
- Fòrmula: C19H19N3O5S
- Peso molecular:401.44
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Publications Citing Use of MedChemExpress (MCE) Oxacillin
More- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Front Microbiol. 2020 Jul 31:11:1720. [Abstract]
- BMC Microbiol. 2023 Apr 20;23(1):109. [Abstract]
- ACS Omega. 2022 Mar 3;7(10):9004-9014. [Abstract]
- Microorganisms. 2024 Jan 25;12(2):256. [Abstract]
- iScience. 2022 Jan 5;25(2):103731. [Abstract]
- Microbiol Spectr. 2022 Apr 27;10(2):e0054121. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- Curr Microbiol. 2023 May 31;80(7):230. [Abstract]
- bioRxiv. 2025 Oct 27.
- bioRxiv. 2024 May 10.
- Research Square Print. December 5th, 2022.
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Microbiological Assay
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Actividad biológica
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β-lactam |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
35 μM
Compound: Oxacillin
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Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
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[PMID: 23344796] |
Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively[1].
The Oxacillin-resistant strains are highly resistant to other penicillins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 strain male albino mice infected with S. aureus Evans[2]
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Dosage:50, 100, 200, 400 and 800 mg/kg
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Administration:Subcutaneous injection, once
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Result:Showed therapeutic activity with CD50 of 253.3 mg/kg.
Chemical Information
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No. CAS 66-79-5
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Peso molecular 401.44
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Fòrmula C19H19N3O5S
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SMILES
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=CC=CC=C4)=O)N1C2=O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Front Microbiol
Repurposing Antispasmodic Agent Otilonium Bromide for Treatment of Staphylococcus aureus Infections. [Abstract]2020 Jul 31:11:1720. PMID: 32849366 -
BMC Microbiol
The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin. [Abstract]2023 Apr 20;23(1):109. PMID: 37081393 -
ACS Omega
Lapatinib Acts against Biofilm Formation and the Hemolytic Activity of Staphylococcus aureus. [Abstract]2022 Mar 3;7(10):9004-9014. PMID: 35309438 -
Microorganisms
The Staphylococcus aureus ArlS Kinase Inhibitor Tilmicosin Has Potent Anti-Biofilm Activity in Both Static and Flow Conditions. [Abstract]2024 Jan 25;12(2):256. PMID: 38399660 -
iScience
2022 Jan 5;25(2):103731. PMID: 35098100 -
Microbiol Spectr
Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein. [Abstract]2022 Apr 27;10(2):e0054121. PMID: 35234502 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Oxacillin purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
Curr Microbiol
Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes. [Abstract]2023 May 31;80(7):230. PMID: 37256372 -
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxacillin Related Classifications
HY-B0925A Related Classifications
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