Polymyxin B
Based on 26 publication(s) in Google Scholar
Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research.
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- Pureza: 92.99%
- No. CAS: 1404-26-8
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Polymyxin B
More- Science. 2026 Mar 19;391(6791):eadu7686. [Abstract]
- ACS Nano. 2021 Mar 23;15(3):4173-4185. [Abstract]
- J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]
- Adv Sci (Weinh). 2026 Jan 28:e13015. [Abstract]
- J Control Release. 2025 May 30:113907. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
- Transl Psychiatry. 2022 Apr 7;12(1):146. [Abstract]
- Int J Pharm. 2022 Jan 25:612:121356. [Abstract]
- Microb Cell Fact. 2026 Jan 27;25(1):50. [Abstract]
- Int J Antimicrob Agents. 2025 Jun 9:107551. [Abstract]
- Sci Rep. 2026 May 30. [Abstract]
- iScience. 2024 Sep 24;27(10):111027. [Abstract]
- J Antimicrob Chemother. 2026 Jun 3;81(7):dkag204. [Abstract]
- Agronomy. 2024 Feb 8, 14(2), 351.
- Microbiol Spectr. 2022 Apr 27;10(2):e0273021. [Abstract]
- J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615. [Abstract]
- Chem Biodivers. 2026 Feb;23(2):e02168. [Abstract]
- Infect Genet Evol. 2025 Sep:133:105780. [Abstract]
- SSRN. 2026 May 6.
- ArXiv. 2025 Nov 7.
- bioRxiv. 2025 January 19.
- bioRxiv. 2024 Dec 2:2024.11.27.625634. [Abstract]
- bioRxiv. 2024 May 10.
- Prince of Songkla University. 2023 Dec.
- Biomed Pharmacother. 2023 Dec 31:169:115856. [Abstract]
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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Actividad biológica
Polymyxin B (10 μg/mL, 6 h) decreases the TNF-α and IL-10 production in Human peripheral blood mononuclear cells (PBMC) [3].
Polymyxin B shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Polymyxin B (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old, 24-30 g, female Swiss mice[2]
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Dosage:0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection model
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Administration:S.c.
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Result:Showed antibacterial activities for three K. pneumoniae strains.
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Animal Model:7-9 weeks, female NMRI mice (E. coli IH3080)[3]
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Dosage:2 mg/kg
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Administration:S.c.
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Result:Decreased the bacterial count in a dose dependent manner.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1404-26-8
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Appearance Solid
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Color White to light yellow
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SMILES
[Polymyxin B]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (26)
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Journal Impact Factor
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Most Recent
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Science
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors. [Abstract]2026 Mar 19;391(6791):eadu7686. PMID: 41855345 -
ACS Nano
Bacteria - Anchoring Hybrid Liposome Capable of Absorbing Multiple Toxins for Antivirulence Therapy of Escherichia coli Infection. [Abstract]2021 Mar 23;15(3):4173-4185. PMID: 33606516 -
J Nanobiotechnology
A novel tetrahedral framework nucleic acid-based antibiotic delivery system: overcoming biofilm barriers to combat chronic infections. [Abstract]2025 Jul 1;23(1):465. PMID: 40597263
Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]
Electrophoretic migration of Td and the Polymyxin B@Td nanocomplex at different gradient mixture ratios (Polymyxin B: Td = 10:1, 50:1, and 100:1).
Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]
Analysis of the zeta potentials of Polymyxin B, Td, and the Polymyxin B@Td nanocomplex.
Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]
Penetration of free or Td-bound Polymyxin B into a bacterial biofilm, as characterized by CLSM (blue: Hoechst33342-stained bacteria; green: FITC-labeled Td; red: Cy5-labeled Polymyxin B). Scale bar: 50 μm.
Polymyxin B purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Jul 1;23(1):465. [Abstract]
SEM analysis of biofilm structural disruption by Polymyxin B and Polymyxin B@Td. Red arrows: biofilm matrix components. Red dotted-line square: representative dead bacteria. Scale bar: 5–3 μm.
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Adv Sci (Weinh)
2026 Jan 28:e13015. PMID: 41603252 -
J Control Release
Functional lipid nanoparticles for safe delivery of macromolecular antibiotics to gram-negative bacteria. [Abstract]2025 May 30:113907. PMID: 40451556
Polymyxin B purchased from MedChemExpress. Usage Cited in: J Control Release. 2025 May 30:113907. [Abstract]
Antimicrobial effects of PMB-LNPs. MIC and Polymyxin B values of Polymyxin B -LNPs or free Polymyxin B against E. coli, A. baumannii.
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Mater Today Bio
Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant Klebsiella pneumoniae. [Abstract]2025 Feb 18:31:101590. PMID: 40104651
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
The cytotoxicity assessment of PEG-pHSA@PMB nanoparticles. The toxicity of Polymyxin B Sulfate (PMB, 24 h), PEG-pHSA@PMB, and PEG-pHSA to HBE cells was detected by the CCK-8 kit.
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
Polymyxin B Sulfate, 4 μg/mL. The bacteriostasis curves of the drugs. The OD600 value of the CRKP suspension was determined at different times.
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
The load of CRKP in the lungs of mice that inhaled different drugs. The bacterial load of CRKP in the lungs of pneumonia mice treated with inhaled drugs (equivalent to 4 mg/kg loaded Polymyxin B Sulfate) was measured by the bacterial plate counting method.
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). HE staining of lung sections of CRKP pneumonia mice treated with different drugs. The scale bar is 50 μm.
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
PEG-pHSA@PMB (4 mg/kg loaded Polymyxin B Sulfate). The statistical chart of lung injury score by HE staining of lung tissue in each group, n = 9.
Polymyxin B purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Feb 18:31:101590. [Abstract]
HE staining of different tissues in mice treated with different drugs. The HE staining results of the lungs, kidneys, brains, hearts, livers, and spleens of ICR mice were examined after inhaling 30 μL of different drugs (equivalent to 8 mg/kg loaded Polymyxin B Sulfate) three times daily for 3 days, n = 5. The scale bar is 100 μm.
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Transl Psychiatry
2022 Apr 7;12(1):146. PMID: 35393390 -
Int J Pharm
Bacteria-targeting liposomes for enhanced delivery of cinnamaldehyde and infection management. [Abstract]2022 Jan 25:612:121356. PMID: 34919996 -
Microb Cell Fact
sRNA196 promotes Pseudomonas aeruginosa virulence by regulating target genes PA4398, ZapE and PhoB. [Abstract]2026 Jan 27;25(1):50. PMID: 41593714 -
Int J Antimicrob Agents
Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae. [Abstract]2025 Jun 9:107551. PMID: 40499596 -
Sci Rep
Effect of polymyxin resistance evolution on the fitness costs of Acinetobacter baumannii and the underlying mechanisms of polymyxin resistance. [Abstract]2026 May 30. PMID: 42218246 -
iScience
TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein. [Abstract]2024 Sep 24;27(10):111027. PMID: 39435149 -
J Antimicrob Chemother
Harnessing metabolic dependence-driven antibiotic synergy to eradicate tolerant Pseudomonas aeruginosa. [Abstract]2026 Jun 3;81(7):dkag204. PMID: 42267541 -
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Microbiol Spectr
Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis. [Abstract]2022 Apr 27;10(2):e0273021. PMID: 35377227 -
J Antimicrob Chemother
Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. [Abstract]2020 Sep 1;75(9):2609-2615. PMID: 32591806 -
Chem Biodivers
Physicochemical Characterization and Bioactivities of Polysaccharides From Siraitia grosvenorii: Effects of Different Extraction Methods. [Abstract]2026 Feb;23(2):e02168. PMID: 41674292 -
Infect Genet Evol
Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE. [Abstract]2025 Sep:133:105780. PMID: 40480594 -
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bioRxiv
Dynamic heterogeneity in an E. coli stress response regulon mediates gene activation and antimicrobial peptide tolerance. [Abstract]2024 Dec 2:2024.11.27.625634. PMID: 39677761 -
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Biomed Pharmacother
The enhancement effect of small molecule Lyb24 reveals AzoR as a novel target of polymyxin B. [Abstract]2023 Dec 31:169:115856. PMID: 37949698
Solvente y solubilidad
0.5 M HCl : ≥ 50 mg/mL
H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with HCl)
H2O : 33.33 mg/mL (ultrasonic and adjust pH to 2 with 1 M HCl)
* "≥" means soluble, but saturation unknown.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Danner RL, et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. [Content Brief]
[2]. Landersdorfer CB, et al. Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models. J Antimicrob Chemother. 2018 Feb 1;73(2):462-468. [Content Brief]
[3]. Vingsbo Lundberg C, et al. Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice. J Antimicrob Chemother. 2010 May;65(5):981-5. [Content Brief]
[4]. Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polymyxin B Related Classifications
HY-149179 Related Classifications
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