Ponometrep
Based on 1 Customer Validation
Ponometrep (BHV-2100) is a transient receptor potential melastatin 3 (TRPM3) antagonist with IC50 values of 1-10 nM. Ponometrep shows analgesic activity and can be used for the research of neurological diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.28%
- No. CAS: 2776175-74-5
- Fòrmula: C18H19N3O5S
- Peso molecular:389.43
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Neuronal Signaling Compound Library
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Clinical Compound Library
HY-L026
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Drug Repurposing Compound Library
HY-L035
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Mechanoreceptors Compound Library
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Ion Channel Compound Library
HY-L166
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Bioactive Compound Library Max
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Actividad biológica
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TRPM3 1-10 nM (IC50) |
Ponometrep inhibits human, mouse, and rat TRPM3 with IC50 values between 1-10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2776175-74-5
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Appearance Solid
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Peso molecular 389.43
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Fòrmula C18H19N3O5S
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Color White to light yellow
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SMILES
CC1=NC=C(S1)COC2=CC=C3OC(C)=C(C3=C2)C(N[C@H](C(N)=O)CO)=O
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Synonyms
BHV-2100
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (128.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5679 mL | 12.8393 mL | 25.6786 mL | 64.1964 mL |
| 5 mM | 0.5136 mL | 2.5679 mL | 5.1357 mL | 12.8393 mL | |
| 10 mM | 0.2568 mL | 1.2839 mL | 2.5679 mL | 6.4196 mL | |
| 15 mM | 0.1712 mL | 0.8560 mL | 1.7119 mL | 4.2798 mL | |
| 20 mM | 0.1284 mL | 0.6420 mL | 1.2839 mL | 3.2098 mL | |
| 25 mM | 0.1027 mL | 0.5136 mL | 1.0271 mL | 2.5679 mL | |
| 30 mM | 0.0856 mL | 0.4280 mL | 0.8560 mL | 2.1399 mL | |
| 40 mM | 0.0642 mL | 0.3210 mL | 0.6420 mL | 1.6049 mL | |
| 50 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.2839 mL | |
| 60 mM | 0.0428 mL | 0.2140 mL | 0.4280 mL | 1.0699 mL | |
| 80 mM | 0.0321 mL | 0.1605 mL | 0.3210 mL | 0.8025 mL | |
| 100 mM | 0.0257 mL | 0.1284 mL | 0.2568 mL | 0.6420 mL |
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