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Referencia número: HY-149616

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PPM-3

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Based on 1 Customer Validation

PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC₅₀ of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages.

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No. CAS: 3032388-42-1
Fòrmula: C₅₄H₆₉N₁₁O₆S
Peso molecular:1000.26

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PPM-3 Chemical Structure

No. CAS: 3032388-42-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Descripciòn
- IC₅₀ & Target
- In Vitro
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Actividad biológica

Descripciòn

IC₅₀ & Target

ERK5

62.4 ± 18. nM (IC₅₀)

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas ERK :

In Vitro

PPM-3 (200 nM, 0-72 h, A375 cells)-mediated degradation of ERK5 begins within 2-4 h and that degradation peaks at 12 h and lasts at least 72 h^[1].
PPM-3 (0-1 μM, 12 h) shows ERK5 degradation activity in H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375 cancer cell lines, with DC₅₀ values of 11.5+2.5, 13.7+8.2, 22.7+13.3, 23.5+10.3, 5.6+1.9, and 41.4+22.3 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3032388-42-1
Appearance Solid
Peso molecular 1000.26
Fòrmula C₅₄H₆₉N₁₁O₆S
Color White to off-white
SMILES

O=C(C1=CC=CC=C1N(C)C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)CCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(N[C@H](C6=CC=C(C=C6)C7=C(N=CS7)C)C)=O)O)=O)=O)=NC=C28)N8C
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Pan P, et al. Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5. J Med Chem. 2023 Oct 12;66(19):13568-13586. [Content Brief]

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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PPM-3

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas ERK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PPM-3 Related Classifications

HY-149616 Related Classifications