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Referencia número: HY-124364

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RO6889678

Name: RO6889678
Brand: MedChemExpress
SKU: HY-124364
Price: 230.00 USD
Availability: InStock
Rating: 5 (1 reviews)

RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation.

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No. CAS: 1578153-27-1
Fòrmula: C₂₁H₂₀ClFN₄O₅S
Peso molecular:494.92

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

RO6889678 Chemical Structure

No. CAS: 1578153-27-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- IC₅₀ & Target
- Cellular Effect
- Ensayo clínico
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

CYP3A4

Ver todos los productos específicos de isoformas Cytochrome P450 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>30 μM Compound: (R)-52	Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay	[PMID: 29381358]
HepG2 2.2.15	EC₅₀	0.003 μM Compound: HAP_R10	Antiviral activity against HBV stably transfected in human HepG2.2.15 cells assessed as reduction of HBV DNA replication incubated for 5 days by q-PCR analysis Antiviral activity against HBV stably transfected in human HepG2.2.15 cells assessed as reduction of HBV DNA replication incubated for 5 days by q-PCR analysis	[PMID: 36896968]

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 1578153-27-1
Peso molecular 494.92
Fòrmula C₂₁H₂₀ClFN₄O₅S
SMILES

O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nicole A Kratochwil, et al. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018 May;365(2):237-248. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- Ensayo clínico
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RO6889678

4,5-Dicaffeoylquinic acid

Morphothiadin

Bay 41-4109 racemate

AB-423

JNJ-632

4,5-Dicaffeoylquinic acid (Standard)

Bay 41-4109 racemate (Standard)

Morphothiadin (Standard)

Ver todos los productos específicos de isoformas Cytochrome P450

Actividad biológica

Chemical Information

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Bioz

RO6889678

4,5-Dicaffeoylquinic acid

Morphothiadin

Bay 41-4109 racemate

AB-423

JNJ-632

4,5-Dicaffeoylquinic acid (Standard)

Bay 41-4109 racemate (Standard)

Morphothiadin (Standard)

Ver todos los productos específicos de isoformas Cytochrome P450

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

RO6889678 Related Classifications

HY-124364 Related Classifications

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