2438 Results for "

decrease

" in MedChemExpress (MCE) Product Catalog:
Products (2438)

2438 Results for "decrease" in MCE Product Catalog:

Leucic acid
Leucic acid
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Referencia número: HY-30216A
No. CAS: 498-36-2
Synonyms: α-Hydroxyisocaproic acid
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Hydroxycarboxylic Acid Receptor (HCAR) AMPK ERK

Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .
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Lidocaine (GMP)
Lidocaine (GMP)
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Referencia número: HY-B0185G
No. CAS: 137-58-6
Synonyms: Lignocaine (GMP)
Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
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Metaxalone
Metaxalone
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Referencia número: HY-B0678
No. CAS: 1665-48-1
Synonyms: AHR438; NSC170959
Target:  

NF-κB PGC-1α

Áreas de investigación:  

Neurological Disease Inflammation/Immunology

Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .
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MCPA (Standard)
MCPA (Standard)
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Referencia número: HY-B0859R
No. CAS: 94-74-6
Target:  

Herbicide Reference Standards Cytochrome P450

Áreas de investigación:  

Metabolic Disease

MCPA (Standard) is the analytical standard of MCPA (HY-B0859). This product is intended for research and analytical applications. MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .
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MCPA-13C8
MCPA-13C8
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Referencia número: HY-B0859S
Synonyms: 4-Chloro-2-Methylphenoxyacetic acid-13C8
MCPA- 13C8 is the 13C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds .
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cis-Mulberroside A
cis-Mulberroside A
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Referencia número: HY-N0619A
No. CAS: 166734-06-1
Synonyms: Mulberroside D
Category:  

Plant Stilbenes Moraceae Extract Phenols Polyphenols Morus alba Linn. Extract Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related Tyrosinase

cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
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Shikonin (Standard)
Shikonin (Standard)
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Referencia número: HY-N0822R
No. CAS: 517-89-5
Synonyms: C.I. 75535 (Standard); Isoarnebin 4 (Standard)
Category:  

Quinones Plant Lithospermum erythrorhizon Sieb. et Zucc. Extract Boraginaceae Extract Naphthalene Quinones

Target:  

Reference Standards Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2

Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .
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Citric acid monohydrate (Standard)
Citric acid monohydrate (Standard)
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Referencia número: HY-N1428AR
No. CAS: 5949-29-1
Citric acid monohydrate (Standard) is the analytical standard of Citric acid monohydrate (HY-N1428A). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Citric acid-d4
Citric acid-d4
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Referencia número: HY-N1428S
No. CAS: 147664-83-3
Citric acid-d4 is the deuterium labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Citric acid-13C6
Citric acid-13C6
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Referencia número: HY-N1428S1
No. CAS: 287389-42-8
Citric acid- 13C6 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Citric acid-13C2
Citric acid-13C2
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Referencia número: HY-N1428S2
No. CAS: 224054-26-6
Citric acid- 13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Citric acid-13C3
Citric acid-13C3
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Referencia número: HY-N1428S3
No. CAS: 302912-06-7
Citric acid- 13C3 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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Citric acid-d4-1
Citric acid-d4-1
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Referencia número: HY-N1428S6
Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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D(+)-Raffinose pentahydrate
D(+)-Raffinose pentahydrate
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Referencia número: HY-N1938
No. CAS: 17629-30-0
Synonyms: D-Raffinose pentahydrate
Category:  

Plant Polysaccharides Other Diseases Other Families Extract Endogenous metabolite Disease Research Fields Saccharides

Target:  

Endogenous Metabolite Glucosylceramide Synthase (GCS) Bacterial Phosphodiesterase (PDE) Interleukin Related

D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA (Kd = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and IL-5 mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia .
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Cucurbitacin IIb (Standard)
Cucurbitacin IIb (Standard)
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Referencia número: HY-N1987R
No. CAS: 50298-90-3
Category:  

Triterpenes Plant Terpenoids Cucurbitaceae Extract Hemsleya amabilis Diels Extract

Target:  

Reference Standards Apoptosis

Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .
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Cajanin
Cajanin
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Referencia número: HY-N2983
No. CAS: 32884-36-9
Category:  

Leguminosae/Fabaceae Extract Plant Flavonoids Other Diseases Rhynchosia edulis Griseb. Extract Phenols Polyphenols Disease Research Fields Isoflavones

Target:  

Tyrosinase

Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .
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Lucidone
Lucidone
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Referencia número: HY-N3364
No. CAS: 19956-53-7
Category:  

Natural Products Plant Lauraceae Extract Lindera lucida (Blume) Boerl. Extract

Target:  

Flavivirus Dengue Virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) .
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PQK7
PQK7
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Referencia número: HY-P11908
Target:  

α-synuclein Apoptosis Reactive Oxygen Species (ROS)

Áreas de investigación:  

Neurological Disease

PQK7 is an α-synuclein (α-synuclein) binder with a Kd value of 4 μM. PQK7 binds to key residues in the NAC region of ⍺-Syn, enhances the fluctuation of ⍺-Syn, reduces β-sheet content, maintains the solubility of ⍺-Syn monomers, and preserves the normal function of the protein. PQK7 reduces the toxicity of ⍺-Syn aggregates, restores cell cycle progression, decreases apoptosis (apoptosis), and inhibits ROS production. PQK7 can be used for the research of Parkinson's disease .
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H-77
H-77
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Referencia número: HY-P2647
No. CAS: 82131-82-6
Target:  

Renin Angiotensin Receptor

Áreas de investigación:  

Cardiovascular Disease

H-77 is a selective Renin inhibitor with an IC50 of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system .
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Survodutide TFA
Survodutide TFA
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Referencia número: HY-P4146A
Synonyms: BI 456906 TFA
Target:  

GLP Receptor GCGR

Áreas de investigación:  

Metabolic Disease

Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
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