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Referencia número: HY-N15315

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Triptriolide

Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin.

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No. CAS: 137131-18-1
Fòrmula: C₂₀H₂₆O₇
Peso molecular:378.42

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Triptriolide Chemical Structure

No. CAS: 137131-18-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas MAP3K :

Ver todos los productos específicos de isoformas NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	>10 μM Compound: 8d	Cytotoxicity against human BGC-823 cells by MTT assay Cytotoxicity against human BGC-823 cells by MTT assay	[PMID: 33289552]
HCT-116	IC₅₀	>10 μM Compound: 8d	Cytotoxicity against human HCT-116 cells by MTT assay Cytotoxicity against human HCT-116 cells by MTT assay	[PMID: 33289552]
HepG2	IC₅₀	>10 μM Compound: 8d	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 33289552]

Chemical Information

No. CAS 137131-18-1
Peso molecular 378.42
Fòrmula C₂₀H₂₆O₇
SMILES

C[C@@]12[C@@]34[C@]5([C@@H]([C@@](O)([C@@H]([C@]3([H])O4)O)C(C)C)O)[C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang YQ, et al., Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival. Biomed Pharmacother. 2019 Jan;109:1932-1939. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Triptriolide

Ver todos los productos específicos de isoformas MAP3K

Ver todos los productos específicos de isoformas NF-κB

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Triptriolide Related Classifications

HY-N15315 Related Classifications