Eif4e - eukaryotic translation initiation factor 4E Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117045

Summary

Enables eukaryotic initiation factor 4G binding activity. Involved in lung development. Part of eukaryotic translation initiation factor 4F complex. Is active in glutamatergic synapse and postsynaptic cytosol. Biomarker of vascular dementia. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Apr 2022]

Eif4e Products (1)

mRNA Protein Name
NM_053974.2 NP_446426.1 eukaryotic translation initiation factor 4E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables eukaryotic initiation factor 4G binding IPI
IPI: Inferred from physical interaction
18952566 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18952566 RGD
Biological Process GO Annotation Evidence References Source
involved in lung development IEP
IEP: Inferred from expression pattern
18952566 RGD
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 4F complex IDA
IDA: Inferred from direct assay
18952566 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11756682 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
12711090 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
11756682 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
18952566 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E

  • eIF-4E

  • eIF-4F 25 kDa subunit

  • eukaryotic initiation factor 4E

  • mRNA cap-binding protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100022 Tomivosertib Inhibitor 99.92% Phase 2
HY-16366 Briciclib 99.45% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19831 4EGI-1 98.69% Unkown
HY-145974A m7GpppAmpG ammonium solution (100 mM) 99.96% Unkown
HY-14427 4E1RCat Inhibitor 99.04% Unkown
HY-159059 Ganoderma lucidum polysaccharide 41.20% Unkown
HY-145262 eIF4E-IN-2 Inhibitor 98.91% Unkown
HY-145969A β-S-ARCA triammonium 99.48% Unkown
HY-100733 4E2RCat Inhibitor 98.0% Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-19831A (Z)-4EGI-1 Inhibitor 98.0% Unkown
HY-176428 PROTAC MNK1 degrader-1 98.93% Unkown
HY-146805 EB1 99.91% Unkown
HY-RS04274 EIF4E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114267 Cbz-B3A Inhibitor 98.63% Unkown
HY-148105 DS12881479 99.63% Unkown
HY-145309 eIF4E-IN-3 Inhibitor / Unkown
HY-145969 β-S-ARCA / Unkown
HY-139098A 7-Methyl-diguanosine triphosphate ammonium solution (100 mM) 98.83% Unkown
HY-178672A ARCA triammonium solution (100 mM) / Unkown
HY-100022A Tomivosertib hydrochloride Inhibitor / Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-145974AGL m7GpppAmpG ammonium solution (100 mM) (GMP like) / Unkown
HY-148664 eIF4E-IN-4 Inhibitor / Unkown
HY-155337 eIF4E-IN-6 Inhibitor / Unkown
HY-155676 eIF4E-IN-5 Inhibitor / Unkown
HY-163479 MNK1/2-IN-7 Inhibitor / Unkown
HY-16366A Briciclib sodium / Unkown
HY-176288 eIF4E/eIF4G PPI-IN-1 / Unkown
HY-182046 HD202A / Unkown
HY-182939 MNK1/2-IN-10 Inhibitor / Unkown
HY-182957 MNK/PIM-IN-2 / Unkown
HY-184004 NUCC-0231068 Inhibitor / Unkown
HY-RS04275 EIF4E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W846144 ETP-45835 Inhibitor / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-139098 7-Methyl-diguanosine triphosphate / Unkown
HY-145974 m7GpppAmpG / Unkown
HY-145976 m7GpppGpG / Unkown
HY-168326 Antiproliferative agent-64 Inhibitor / Unkown
HY-172457 NUCC-0200808 Inhibitor / Unkown
HY-182704 SBI-5844 Inhibitor / Unkown
HY-RS17829 Eif4e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24297 Eif4e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4e NCBI NCBI:1977