Xiap - X-linked inhibitor of apoptosis Gene

Also Known as Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11798

About Xiap

Chromosome X: 41,148,556-41,198,533 forward strand.GRCm39:CM001013.3

This gene has 11 transcripts (splice variants), 217 orthologues, 10 paralogues and is associated with 15 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues.

Summary

The protein encoded by this gene is a member of the inhibitor of Apoptosis (IAP) family of proteins. While first identified for its role in blocking Apoptosis, this protein modulates many Other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks Apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 Ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Xiap Products (3)

mRNA Protein Name
NM_001301641.1 NP_001288570.1 E3 ubiquitin-protein ligase XIAP
NM_001301639.1 NP_001288568.1 E3 ubiquitin-protein ligase XIAP
NM_009688.3 NP_033818.2 E3 ubiquitin-protein ligase XIAP

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11604410 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
14623868 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12153481 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12011074 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
14623868 MGI
involved in regulation of apoptosis involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
30389919 MGI
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
35263589 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15737931 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Xiap Protein Structure

BIR

BIR: cd00022 (27 - 94)

BIR

BIR: smart00238 (161 - 231)

BIR

BIR: smart00238 (263 - 329)

UBA_BIRC4_8

UBA_BIRC4_8: cd14395 (368 - 417)

RING-HC_BIRC4_8

RING-HC_BIRC4_8: cd16714 (432 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase XIAP

  • IAP homolog A

  • RING-type E3 ubiquitin transferase XIAP

  • X-linked IAP

  • baculoviral IAP repeat-containing protein 4

  • inhibitor of apoptosis protein 3

Xiap Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Xiap Q60989 Htra2 Mus musculus Q9JIY5
Anti Tag CoIP
11604410
Intra
Xiap Q60989 Hccs Mus musculus P53702
Pull Down
16858406
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15454 Xevinapant Antagonist 99.91% Phase 3
HY-13208 Xevinapant hydrochloride Antagonist 98.11% Phase 3
HY-168739 Topoisomerase I inhibitor 17 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12600 AZD5582 Antagonist 99.61% Unkown
HY-17473 Embelin Antagonist 99.01% Unkown
HY-N0732 Jolkinolide B Inhibitor 99.65% Unkown
HY-110346 AZD5582 dihydrochloride Antagonist 99.92% Unkown
HY-151966 TD1092 Degrader 99.49% Unkown
HY-178226 PBX-7016 Inhibitor / Unkown
HY-125378 SBP-0636457 Antagonist 98.42% Unkown
HY-175352 Nurr1 agonist 14 Inducer 99.42% Unkown
HY-179633 ZLMT-72 Inhibitor / Unkown
HY-N18315 (2''S)-2'',3''-Dihydrodelicaflavone Modulator / Unkown
HY-111886 KHS108-MV1 Antagonist / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-102051 XIAP/cIAP1 antagonist-1 Inhibitor / Unkown
HY-118522 TP-110 Inhibitor / Unkown
HY-175444 XIAP ligand-Linker Conjugate 1 Antagonist / Unkown
HY-175449 XIAP ligand 5 Antagonist / Unkown
HY-181533 IAP ligand 9 Ligand / Unkown
HY-12440 HM90822 Antagonist / Unkown
HY-123925 CSLP43 Inhibitor / Unkown
HY-179023 CDK9-IN-45 Inhibitor / Unkown
HY-175348 XB2M54 Antagonist / Unkown
HY-175450 XIAP ligand-Linker Conjugate 2 Antagonist / Unkown
HY-100682 T-3256336 Inhibitor / Unkown
HY-175448 GNE-1567 Antagonist / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-181018 Topo I/DDX5-IN-1 Inhibitor / Unkown
HY-175925 XIAP ligand 6 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xiap NCBI NCBI:331