XIAP - X-linked inhibitor of apoptosis Gene

Also Known as API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 331

About XIAP

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:123,859,708-123,913,972 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 10.5), colon (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits Apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the Caspase family of cell-death proteases, Caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

XIAP Products (7)

mRNA	Protein	Name
NM_001378590.1	NP_001365519.1	E3 ubiquitin-protein ligase XIAP
NM_001378591.1	NP_001365520.1	E3 ubiquitin-protein ligase XIAP
NM_001167.4	NP_001158.2	E3 ubiquitin-protein ligase XIAP
NM_001378592.1	NP_001365521.1	E3 ubiquitin-protein ligase XIAP
NR_165803.1
NR_037916.2
NM_001204401.2	NP_001191330.1	E3 ubiquitin-protein ligase XIAP

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11257230	GOA
enables endopeptidase regulator activity	IDA IDA: Inferred from direct assay	11257230	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11140638	GOA
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	11865055	GOA
enables ubiquitin protein ligase activity	EXP EXP: Inferred from Experiment	22304967	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	29452636	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19473982	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	29020630	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IEP IEP: Inferred from expression pattern	18049476	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	29452636	GOA
involved in inhibition of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11865055	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11257230	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18049476	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11583623	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	11865055	GOA
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA IDA: Inferred from direct assay	29452636	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	19667203	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	11865055	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19667203	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22304967	GOA
involved in positive regulation of protein linear polyubiquitination	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	36394357	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	29452636	GOA
acts upstream of negative effect regulation of apoptotic process	IDA IDA: Inferred from direct assay	11865055	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15665297	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22304967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XIAP Protein Structure

BIR

zf-C3HC4_3

0
100
200
300
400
497 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase XIAP	IAP-like protein 1 RING-type E3 ubiquitin transferase XIAP X-linked IAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase baculoviral IAP repeat-containing protein 4 inhibitor of apoptosis protein 3

XIAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XIAP	P98170	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	32296183
Intra	XIAP	P98170	UBE2V1	Homo sapiens	Q13404	Y2H Array	19549727
Intra	XIAP	P98170	ERCC3	Homo sapiens	P19447	Validated Y2H	25416956
Intra	XIAP	P98170	ERCC3	Homo sapiens	P19447	Y2H Array	25416956
Intra	XIAP	P98170	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	XIAP	P98170	DIABLO	Homo sapiens	Q9NR28-1	Pull Down	19667203
Intra	XIAP	P98170	HTRA4	Homo sapiens	P83105	Protease Assay	31470122
Intra	XIAP	P98170	HTRA3	Homo sapiens	P83110-2	PLA	31260151
Intra	XIAP	P98170	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	XIAP	P98170	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	25416956
Intra	XIAP	P98170	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Cross	XIAP	P98170	Htra2	Mus musculus	Q9JIY5	Anti Tag CoIP	11604410
Cross	XIAP	P98170	Q9JIQ3-PRO_0000021073	Mus musculus	Q9JIQ3-PRO_0000021073	Anti Tag CoIP	23818254
Intra	XIAP	P98170	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	XIAP	P98170	HTRA3	Homo sapiens	P83110	Protease Assay	31470122
Intra	XIAP	P98170	UBE2D2	Homo sapiens	P62837	Y2H Array	19549727
Intra	XIAP	P98170	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	23818254
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	19667203
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Y2H Array	31515488
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Pull Down	21931591
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	38191507
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Anti Bait CoIP	19667203
Intra	XIAP	P98170	RIPK2	Homo sapiens	O43353	Pull Down	19667203
Intra	XIAP	P98170	TAB1	Homo sapiens	Q15750	Anti Tag CoIP	23818254
Intra	XIAP	P98170	PPM1K	Homo sapiens	Q8N3J5	Validated Y2H	32296183
Intra	XIAP	P98170	RAC1	Homo sapiens	P63000	Anti Tag CoIP	22117219
Intra	XIAP	P98170	RAC1	Homo sapiens	P63000	Pull Down	22117219
Intra	XIAP	P98170	SEPTIN4	Homo sapiens	O43236-6	Anti Tag CoIP	21185211
Intra	XIAP	P98170	RIPK4	Homo sapiens	P57078	Pull Down	21931591
Intra	XIAP	P98170	RIPK4	Homo sapiens	P57078	Enzymatic Study	21931591
Intra	XIAP	P98170	CKS1B	Homo sapiens	P61024	Validated Y2H	25416956
Intra	XIAP	P98170	CKS1B	Homo sapiens	P61024	Y2H Array	25416956
Intra	XIAP	P98170	CASP10	Homo sapiens	Q92851	Y2H Array	25416956
Intra	XIAP	P98170	CASP10	Homo sapiens	Q92851	Validated Y2H	25416956
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Y2H Array	31467278
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Pull Down	11801603
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Validated Y2H	25416956
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	FPS	11801603
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	BRET	29997244
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Y2H Pooling	16189514
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Anti Tag CoIP	18022362
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Complementation	31467278
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	PLA	25241761
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Validated Y2H	27107012
Intra	XIAP	P98170	CASP9	Homo sapiens	P55211	Y2H Array	31515488
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	11604410
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	Protease Assay	31470122
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	Pull Down	24698088
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	Anti Bait CoIP	11583623
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	11583623
Intra	XIAP	P98170	HTRA2	Homo sapiens	O43464	SPR	24698088
Intra	XIAP	P98170	DIABLO	Homo sapiens	Q9NR28	FPS	11801603
Intra	XIAP	P98170	DIABLO	Homo sapiens	Q9NR28	Pull Down	11801603
Intra	XIAP	P98170	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	11604410
Intra	XIAP	P98170	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	11801603
Intra	XIAP	P98170	CASP7	Homo sapiens	P55210	Complementation	31467278
Intra	XIAP	P98170	CASP3	Homo sapiens	P42574	Anti Tag CoIP	19273858
Intra	XIAP	P98170	CASP3	Homo sapiens	P42574	Pull Down	9525868
Intra	XIAP	P98170	NOTCH1	Homo sapiens	P46531	Anti Bait CoIP	17318174
Intra	XIAP	P98170	NOTCH1	Homo sapiens	P46531	Anti Tag CoIP	17318174
Intra	XIAP	P98170	RFC5	Homo sapiens	P40937	Validated Y2H	25416956
Intra	XIAP	P98170	RFC5	Homo sapiens	P40937	Y2H Array	29892012
Intra	XIAP	P98170	RFC5	Homo sapiens	P40937	Y2H Array	31515488
Intra	XIAP	P98170	RFC5	Homo sapiens	P40937	Y2H Prey Pooling	25416956
Intra	XIAP	P98170	HEXB	Homo sapiens	P07686	Y2H Array	32814053
Intra	XIAP	P98170	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	XIAP	P98170	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	XIAP	P98170	NEK6	Homo sapiens	Q9HC98	Y2H Prey Pooling	25416956
Intra	XIAP	P98170	NEK6	Homo sapiens	Q9HC98	Y2H Array	25416956
Intra	XIAP	P98170	NTAQ1	Homo sapiens	Q96HA8	Y2H Pooling	16189514
Intra	XIAP	P98170	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	27107012
Intra	XIAP	P98170	UBE2D1	Homo sapiens	P51668	Enzymatic Study	21931591
Intra	XIAP	P98170	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	XIAP	P98170	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	XIAP	P98170	SIAH1	Homo sapiens	Q8IUQ4	Anti Tag CoIP	21185211
Intra	XIAP	P98170	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XIAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73485	XIAP Protein, Human (Avi)	P98170 (L121-T356)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73537	XIAP Protein, Human (His)	P98170 (N252-T356)	≥ 95%, as determined by reducing SDS-PAGE.

XIAP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82684	XIAP Antibody (YA2429)	WB	Human, Mouse, Rat
HY-P82684A	XIAP Antibody (YA2429)(PBS only)	WB	Human, Mouse, Rat
HY-P86214	XIAP Antibody (YA5906)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Alopecia, Androgenetic, 1	Androgenetic Alopecia Androgenic Alopecia AGA1 Aga Female Pattern Baldness Male Pattern Alopecia Male Pattern Baldness Pattern Baldness Alopecia, Androgenetic Alopecia Androgenetic Female Pattern Alopecia
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymphoproliferative Syndrome 1	LPFS1 Lymphoproliferative Syndrome, Ebv-Associated, Autosomal, 1 Combined Immunodeficiency Due To Itk Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Itk Deficiency Itk Deficiency
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Gastrointestinal Defects And Immunodeficiency Syndrome 1	Familial Intestinal Polyatresia Syndrome Fipa Gastrointestinal Defects And Immunodeficiency Syndrome Multiple Gastrointestinal Atresias Familial Isolated Pituitary Adenoma Intestinal Atresia, Multiple Multiple Intestinal Atresia GIDID1 Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Minat Gidid Meddra:10028210 Familial Isolated Pituitary Adenoma Syndrome Intestinal Atresia Multiple Combined Immunodeficiency-Enteropathy Spectrum Cid-Mia/Early-Onset Ibd Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Mia Gastrointestinal Defect And Immunodeficiency Syndrome Pituitary Adenoma Predisposition Pituitary Adenoma, Familial Isolated
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dysgammaglobulinemia
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Griscelli Syndrome, Type 2	Griscelli Syndrome Type 2 GS2 Griscelli Syndrome With Hemophagocytic Syndrome Partial Albinism And Immunodeficiency Syndrome Paid Syndrome Hypopigmentation-Immunodeficiency With Or Without Neurologic Impairment Syndrome Griscelli-Prunieras Syndrome Type 2 Griscelli-Pruniéras Syndrome Type 2 Griscelli Syndrome 2
Griscelli Syndrome	Chediak-Higashi-Like Syndrome Griscelli-Prunieras Syndrome Partial Albinism-Immunodeficiency Syndrome Griscelli Disease Gs Hypopigmentation Immunodeficiency Disease Partial Albinism With Immunodeficiency Immunodeficiency Syndrome With Hypopigmentation Hypopigmentation-Immunodeficiency Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Pancytopenia
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp XLP1 Lyp X-Linked Lymphoproliferative Disease Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Selective Immunoglobulin Deficiency Disease
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Cowpox	Yaba

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13208	Xevinapant hydrochloride	Antagonist	98.11%	Phase 3
HY-109565	Tolinapant		99.81%	Phase 2
HY-168739	Topoisomerase I inhibitor 17	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12600	AZD5582	Antagonist	99.61%	Unkown
HY-15454	Xevinapant	Antagonist	99.91%	Unkown
HY-17473	Embelin	Antagonist	99.01%	Unkown
HY-N0732	Jolkinolide B	Inhibitor	99.65%	Unkown
HY-148837	GT19630	Degrader	98.85%	Unkown
HY-149924	CST626	Degrader	99.60%	Unkown
HY-110346	AZD5582 dihydrochloride	Antagonist	99.92%	Unkown
HY-178226	PBX-7016	Inhibitor	/	Unkown
HY-151966	TD1092	Degrader	98.23%	Unkown
HY-125378	SBP-0636457	Antagonist	98.30%	Unkown
HY-175352	Nurr1 agonist 14	Inducer	99.42%	Unkown
HY-179633	ZLMT-72	Inhibitor	/	Unkown
HY-117356A	MRS2693 ammonium	Activator	/	Unkown
HY-111886	KHS108-MV1	Antagonist	/	Unkown
HY-168893	K882	Inhibitor	/	Unkown
HY-102051	XIAP/cIAP1 antagonist-1	Inhibitor	/	Unkown
HY-175448	GNE-1567	Antagonist	/	Unkown
HY-118522	TP-110	Inhibitor	/	Unkown
HY-181532	IAP ligand 8	Ligand	/	Unkown
HY-109565B	Tolinapant dihydrochloride		/	Unkown
HY-175925	XIAP ligand 6	Ligand	/	Unkown
HY-N18315	(2''S)-2'',3''-Dihydrodelicaflavone	Modulator	/	Unkown
HY-12440	HM90822	Antagonist	/	Unkown
HY-179023	CDK9-IN-45	Inhibitor	/	Unkown
HY-175348	XB2M54	Antagonist	/	Unkown
HY-100682	T-3256336	Inhibitor	/	Unkown
HY-175450	XIAP ligand-Linker Conjugate 2	Antagonist	/	Unkown
HY-175449	XIAP ligand 5	Antagonist	/	Unkown
HY-175444	XIAP ligand-Linker Conjugate 1	Antagonist	/	Unkown
HY-181533	IAP ligand 9	Ligand	/	Unkown
HY-181018	Topo I/DDX5-IN-1	Inhibitor	/	Unkown
HY-123925	CSLP43	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XIAP	MGD	MGI:107572
Rattus norvegicus	XIAP	RGD	RGD:620692
Others	XIAP	NCBI