Cxcl10 - chemokine (C-X-C motif) ligand 10 Gene

Also Known as C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15945

Summary

Predicted to enable chemoattractant activity; Chemokine Receptor binding activity; and heparin binding activity. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl10 Products (1)

mRNA Protein Name
NM_021274.2 NP_067249.1 C-X-C motif chemokine 10 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
30294880 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within negative regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within negative regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19008373 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
11894098 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-X-C motif chemokine 10

  • 10 kDa interferon gamma-induced protein

  • gamma-IP10

  • interferon activated gene 10

  • interferon-gamma induced protein CRG-2

  • small inducible cytokine B subfamily (Cys-X-Cys), member 10

  • small-inducible cytokine B10

Recombinant Cxcl10 Proteins

Cat. No. Product Name Accession Purity
HY-P7227 IP-10/CRG-2/CXCL10 Protein, Mouse P17515 (I22-P98) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700168AF Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His) P17515 (I22-P98) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0426A Olopatadine hydrochloride 99.83% Unkown
HY-W062109 Olopatadine 98.94% Unkown
HY-B0426AR Olopatadine hydrochloride (Standard) / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148511 Vidutolimod 93.85% Phase 3
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99190 Eldelumab Inhibitor 99.50% Phase 2
HY-P990639 NI-0801 99.19% Phase 2
HY-P991582 BI-1607 / Phase 2
HY-P992047 BMS-986184 / Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15319 AMG 487 Inhibitor 99.89% Unkown
HY-15589 GW9508 99.23% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.63% Unkown
HY-15320 NBI-74330 Antagonist 99.76% Unkown
HY-124151 Adenosine-2'-monophosphate Activator 99.91% Unkown
HY-111149A PS372424 hydrochloride Agonist ≥98.0% Unkown
HY-122891 SB02024 99.70% Unkown
HY-152956 STING agonist-23 Agonist 99.33% Unkown
HY-N7688 Regaloside B Inhibitor 99.90% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-162675 COB-187 Inhibitor 95.0% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-111149 PS372424 Agonist / Unkown
HY-RS03384 CXCL10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15589R GW9508 (Standard) 98.07% Unkown
HY-113730 VUF5834 Antagonist / Unkown
HY-147129 cGAS-IN-9 Inhibitor / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-15319A (±)-AMG 487 Inhibitor / Unkown
HY-158036 PROTAC STING Degrader-2 / Unkown
HY-168554 STING Degrader-3 / Unkown
HY-173404 VB-85247 / Unkown
HY-174136 STING Degrader-2 / Unkown
HY-176257 STING agonist-44 Agonist / Unkown
HY-178032 PARP1-IN-44 / Unkown
HY-179288 TPST2-IN-1 Inhibitor / Unkown
HY-181484 STING agonist-50 / Unkown
HY-181877 IHCH-3185 / Unkown
HY-182926 Topoisomerase I/II-IN-9 Inhibitor / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-183607 SMU-3k / Unkown
HY-184500 TNG917 Inhibitor / Unkown
HY-B0426AS2 Olopatadine-d6 hydrochloride / Unkown
HY-W062109S Olopatadine-d6 / Unkown
HY-W104821 Rosolic acid Activator / Unkown
HY-167884 PF-1367550 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown
HY-B0426AS Olopatadine-d3 hydrochloride / Unkown
HY-RS16518 Cxcl10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22949 Cxcl10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991761 Anti-Mouse CXCL10 Antibody (1F11) Inhibitor 97.564% Unkown
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl10 NCBI NCBI:3627