Pgf - placental growth factor Gene
Also Known as PIGF; Plgf
Species: Mus musculus
Summary
Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including brain; gut gland; musculature; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Pgf Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001271705.1 | NP_001258634.1 | placenta growth factor isoform 2 |
| NM_008827.3 | NP_032853.1 | placenta growth factor isoform 1 precursor |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within branching involved in ureteric bud morphogenesis |
IDA
IDA: Inferred from direct assay
|
13678594 | MGI |
| acts upstream of or within gene expression |
IMP
IMP: Inferred from mutant phenotype
|
30179860 | MGI |
| acts upstream of or within glycogen metabolic process |
IGI
IGI: Inferred from genetic interaction
|
30179860 | MGI |
| acts upstream of or within glycogen metabolic process |
IMP
IMP: Inferred from mutant phenotype
|
30179860 | MGI |
| acts upstream of or within placenta development |
IMP
IMP: Inferred from mutant phenotype
|
30179860 | MGI |
| acts upstream of or within regulation of blood pressure |
IGI
IGI: Inferred from genetic interaction
|
30179860 | MGI |
| acts upstream of or within regulation of blood pressure |
IMP
IMP: Inferred from mutant phenotype
|
30179860 | MGI |
| acts upstream of or within regulation of morphogenesis of a branching structure |
IDA
IDA: Inferred from direct assay
|
13678594 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
25184477 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
placenta growth factor |
|
Recombinant Pgf Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70792 | PLGF Protein, Mouse (HEK293, His) | P49764 (V19-P158) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78337 | PLGF Protein, Mouse (HEK293, Fc) | P49764 (V19-P158) | ≥ 95%, as determined by Bis-Tris PAGE. |
Related Agents
- Approval
- Clinical Phase
- Pre-clinical Phase
Approval
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-12956 | Dinoprost | 99.84% | Unkown | |
| HY-12956A | Dinoprost tromethamine salt | 98.0% | Unkown | |
| HY-128428 | Carboprost | 99.84% | Unkown | |
| HY-116733 | Tafluprost ethyl ester | Agonist | / | Unkown |
| HY-124219 | 17-Phenoxy trinor prostaglandin F2α ethyl amide | Agonist | / | Unkown |
Clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-101438 | Darbufelone | Inhibitor | 99.49% | Phase 3 |
| HY-106037 | PGF2α-isopropyl ester | / | Phase 3 | |
| HY-112284 | Ebopiprant | Antagonist | 98.65% | Phase 2 |
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