Atg5 - autophagy related 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 365601

Summary

Involved in several processes, including chaperone-mediated autophagy; response to fluoride; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Biomarker of ischemia. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (Autophagy related 5). [provided by Alliance of Genome Resources, Apr 2022]

Atg5 Products (4)

mRNA Protein Name
NM_001014250.2 NP_001014272.1 autophagy protein 5 isoform 1
NM_001399019.1 NP_001385948.1 autophagy protein 5 isoform 2
NM_001399020.1 NP_001385949.1 autophagy protein 5 isoform 3
NM_001399021.1 NP_001385950.1 autophagy protein 5 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18059433 RGD
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
16420522 RGD
involved in autophagy IMP
IMP: Inferred from mutant phenotype
18059433 RGD
involved in chaperone-mediated autophagy IMP
IMP: Inferred from mutant phenotype
23434281 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20075199 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
30715741 RGD
involved in positive regulation of stress granule assembly IMP
IMP: Inferred from mutant phenotype
30404558 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
24296261 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
23187302 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
25040536 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28231469 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
18059433 RGD
is active in synapse IDA
IDA: Inferred from direct assay
28231469 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

autophagy protein 5

  • ATG5 autophagy related 5 homolog

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W018791 Bifendate 99.92% Unkown
HY-N0538 Xylitol 99.5% Yes
HY-B0960 Sulfabenzamide 99.68% Unkown

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N3415 Kumatakenin 99.31% Unkown
HY-N4120 Valechlorine Inducer / Unkown
HY-RS01152 ATG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23989 Atg5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151914 Antitumor agent-82 Inducer / Unkown
HY-157548 Antitumor agent-133 Inducer / Unkown
HY-167843 Alborixin / Unkown
HY-170594 Antitumor agent-192 Inducer / Unkown
HY-173133 Antitumor agent-199 / Unkown
HY-179052 Apoptosis inducer 50 / Unkown
HY-183730 4E1RCat 17d Inhibitor / Unkown
HY-183731 ATG5 PPI-IN-1 / Unkown
HY-183737 ATG5/TECAIR-IN-1 Inhibitor / Unkown
HY-183738 4E1RCat 27d / Unkown
HY-183807 T1742 Inhibitor / Unkown
HY-183826 ATG5 PPI-IN-4 Inhibitor / Unkown
HY-183827 ATG5 PPI-IN-5 Inhibitor / Unkown
HY-183829 ATG5/TECAIR-IN-3 Inducer / Unkown
HY-183833 Autophagy-IN-9 Inhibitor / Unkown
HY-183835 Autophagy-IN-10 Inhibitor / Unkown
HY-183838 Autophagy-IN-11 Inhibitor / Unkown
HY-183848 ATG5/TECAIR-IN-4 Inhibitor / Unkown
HY-183867 ATG5 PPI-IN-6 Inhibitor / Unkown
HY-184501 UE01 / Unkown
HY-N13352 Bufothionine / Unkown
HY-W768347 Xylitol-13C5 / Unkown
HY-183732 ATG5 PPI-IN-2 Inhibitor / Unkown
HY-183736 Autophagy-IN-12 Inhibitor / Unkown
HY-183828 ATG5/TECAIR-IN-2 Inhibitor / Unkown
HY-RS17532 Atg5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg5 NCBI NCBI:9474