ERBB2 - erb-b2 receptor tyrosine kinase 2 Gene

Canis lupus familiaris (sub-species: familiaris)

Also known as HER-2; c-erbB-2; p185erbB2

Gene ID: 403883 | Gene type: protein coding

About ERBB2

Primary_assembly 9: 23,553,919-23,606,691 reverse strand.ROS_Cfam_1.0:CM025108.1

This gene has 5 transcripts (splice variants), 200 orthologues and 54 paralogues.

mRNA	Protein	Name
NM_001003217.3	NP_001003217.3	receptor tyrosine-protein kinase erbB-2 precursor

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB2

PTKc_HER2

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-2

proto-oncogene c-ErbB-2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Cat. No.	Product Name	Accession	Purity
HY-P74897	HER2/CD340 Protein, Canine (HEK293, His)	A0A8I3NJW9 (T23-T652)	≥95%

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-50898	Lapatinib	99.83%	Yes
HY-13272	Dacomitinib	99.74%	Yes
HY-50898A	Lapatinib ditosylate	99.95%	Yes
HY-50898B	Lapatinib ditosylate monohydrate	99.78%	Yes
HY-50898C	Lapatinib tosylate	/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13314	Tesevatinib	Inhibitor	99.21%	Phase 3
HY-16069A	Tucatinib hemiethanolate	Inhibitor	99.97%	Phase 3
HY-10367	Canertinib	Inhibitor	99.95%	Phase 2
HY-32718	Pelitinib	Inhibitor	98.80%	Phase 2
HY-10045	AEE788		99.13%	Phase 2
HY-10367A	Canertinib dihydrochloride	Inhibitor	99.12%	Phase 2
HY-10322	Falnidamol	Inhibitor	99.05%	Phase 1
HY-10346A	AV-412 free base	Inhibitor	98.33%	Phase 1
HY-103443	HKI-357	Inhibitor	99.65%	Phase 1
HY-116437	Selatinib	Inhibitor	99.83%	Phase 1
HY-10346	AV-412	Inhibitor	99.17%	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13050	Sapitinib	Inhibitor	99.93%	Unkown
HY-13896	PD168393		98.60%	Unkown
HY-101448	TMI-1		99.59%	Unkown
HY-14674	CP-724714		98.53%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-13427	Allitinib tosylate	Inhibitor	99.83%	Unkown
HY-15844	AG-825		98.02%	Unkown
HY-20878	Tyrphostin AG 879		99.85%	Unkown
HY-135366	HPN-01	Inhibitor	98.40%	Unkown
HY-N1166	Tephrosin		≥97.0%	Unkown
HY-150023	BI-1622	Inhibitor	98.97%	Unkown
HY-100499	Tyrphostin AG 528	Inhibitor	≥98.0%	Unkown
HY-101042	AG-494	Inhibitor	99.31%	Unkown
HY-112420	EGFR/ErbB-2/ErbB-4 inhibitor-2	Inhibitor	99.69%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	Unkown
HY-103439	GW583340 dihydrochloride	Inhibitor	/	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	/	Unkown
HY-13272S2	Dacomitinib-d10 dihydrochloride		≥95.0%	Unkown
HY-147407	Imbotolimod		/	Unkown
HY-13272S3	Dacomitinib-d10		/	Unkown
HY-137028	2′-Thioadenosine	Inhibitor	/	Unkown
HY-156639	EGFR/ErbB-2 inhibitor-1	Inhibitor	/	Unkown
HY-160068	2-2(t) aptamer sodium	Chemical	/	Unkown
HY-50898S	Lapatinib-d4		99.02%	Unkown
HY-50898S1	Lapatinib-d7 dihydrochloride		/	Unkown
HY-50898S2	Lapatinib-d5		/	Unkown
HY-50898S3	Lapatinib-d4-1		/	Unkown
HY-P4082	ErbB-2-binding peptide		/	Unkown
HY-RS04466	ERBB2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04467	Erbb2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04468	ERBB2 Rat Pre-designed siRNA Set A		/	Unkown
HY-W008914	(E/Z)-CP-724714	Inhibitor	/	Unkown
HY-15375	Allitinib	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99558	Timigutuzumab	Inhibitor	/	Unkown

Species	Symbol	Source	ID
Homo sapiens	ERBB2	NCBI	NCBI:2064
Macaca fascicularis	ERBB2	NCBI	NCBI:102146608
Mus musculus	ERBB2	NCBI	NCBI:13866
Rattus norvegicus	ERBB2	NCBI	NCBI:24337
Macaca mulatta	ERBB2	NCBI	NCBI:697573

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