MAP4 - microtubule associated protein 4 Gene
Species: Homo sapiens
About MAP4
This gene has 17 transcripts (splice variants) and 35 orthologues. Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues.
Summary
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
MAP4 Products (144)
| mRNA | Protein | Name |
|---|---|---|
| NM_001134364.2 | NP_001127836.1 | microtubule-associated protein 4 isoform 4 |
| NM_001384675.1 | NP_001371604.1 | microtubule-associated protein 4 isoform 92 |
| NM_001384676.1 | NP_001371605.1 | microtubule-associated protein 4 isoform 23 |
| NM_001384677.1 | NP_001371606.1 | microtubule-associated protein 4 isoform 74 |
| NM_001384678.1 | NP_001371607.1 | microtubule-associated protein 4 isoform 55 |
| NM_001384679.1 | NP_001371608.1 | microtubule-associated protein 4 isoform 17 |
| NM_001384680.1 | NP_001371609.1 | microtubule-associated protein 4 isoform 86 |
| NM_001384681.1 | NP_001371610.1 | microtubule-associated protein 4 isoform 56 |
| NM_001384707.1 | NP_001371636.1 | microtubule-associated protein 4 isoform 62 |
| NM_001384729.1 | NP_001371658.1 | microtubule-associated protein 4 isoform 1 |
| NM_001384730.1 | NP_001371659.1 | microtubule-associated protein 4 isoform 26 |
| NM_001384731.1 | NP_001371660.1 | microtubule-associated protein 4 isoform 16 |
| NM_001384733.1 | NP_001371662.1 | microtubule-associated protein 4 isoform 81 |
| NM_001384734.1 | NP_001371663.1 | microtubule-associated protein 4 isoform 40 |
| NM_001384735.1 | NP_001371664.1 | microtubule-associated protein 4 isoform 63 |
| NM_001384736.1 | NP_001371665.1 | microtubule-associated protein 4 isoform 12 |
| NM_001384737.1 | NP_001371666.1 | microtubule-associated protein 4 isoform 32 |
| NM_001384738.1 | NP_001371667.1 | microtubule-associated protein 4 isoform 14 |
| NM_001384744.1 | NP_001371673.1 | microtubule-associated protein 4 isoform 30 |
| NM_001384745.1 | NP_001371674.1 | microtubule-associated protein 4 isoform 10 |
| NM_001384746.1 | NP_001371675.1 | microtubule-associated protein 4 isoform 70 |
| NM_001384748.1 | NP_001371677.1 | microtubule-associated protein 4 isoform 15 |
| NM_001384751.1 | NP_001371680.1 | microtubule-associated protein 4 isoform 66 |
| NM_001384752.1 | NP_001371681.1 | microtubule-associated protein 4 isoform 106 |
| NM_001384753.1 | NP_001371682.1 | microtubule-associated protein 4 isoform 87 |
| NM_001384754.1 | NP_001371683.1 | microtubule-associated protein 4 isoform 38 |
| NM_001384755.1 | NP_001371684.1 | microtubule-associated protein 4 isoform 94 |
| NM_001384756.1 | NP_001371685.1 | microtubule-associated protein 4 isoform 39 |
| NM_001384757.1 | NP_001371686.1 | microtubule-associated protein 4 isoform 104 |
| NM_001384758.1 | NP_001371687.1 | microtubule-associated protein 4 isoform 100 |
| NM_001384759.1 | NP_001371688.1 | microtubule-associated protein 4 isoform 112 |
| NM_001384760.1 | NP_001371689.1 | microtubule-associated protein 4 isoform 120 |
| NM_001384761.1 | NP_001371690.1 | microtubule-associated protein 4 isoform 83 |
| NM_001384762.1 | NP_001371691.1 | microtubule-associated protein 4 isoform 127 |
| NM_001384774.1 | NP_001371703.1 | microtubule-associated protein 4 isoform 22 |
| NM_001384776.1 | NP_001371705.1 | microtubule-associated protein 4 isoform |
| NM_001384777.1 | NP_001371706.1 | microtubule-associated protein 4 isoform 52 |
| NM_001384778.1 | NP_001371707.1 | microtubule-associated protein 4 isoform 122 |
| NM_001384779.1 | NP_001371708.1 | microtubule-associated protein 4 isoform 69 |
| NM_001384780.1 | NP_001371709.1 | microtubule-associated protein 4 isoform 84 |
| NM_001384781.1 | NP_001371710.1 | microtubule-associated protein 4 isoform 36 |
| NM_001384782.1 | NP_001371711.1 | microtubule-associated protein 4 isoform 41 |
| NM_001384783.1 | NP_001371712.1 | microtubule-associated protein 4 isoform 80 |
| NM_001384784.1 | NP_001371713.1 | microtubule-associated protein 4 isoform 132 |
| NM_001384785.1 | NP_001371714.1 | microtubule-associated protein 4 isoform 116 |
| NM_001384786.1 | NP_001371715.1 | microtubule-associated protein 4 isoform 58 |
| NM_001384787.1 | NP_001371716.1 | microtubule-associated protein 4 isoform 117 |
| NM_001384788.1 | NP_001371717.1 | microtubule-associated protein 4 isoform 13 |
| NM_001384789.1 | NP_001371718.1 | microtubule-associated protein 4 isoform 119 |
| NM_001384790.1 | NP_001371719.1 | microtubule-associated protein 4 isoform 50 |
| NM_001384791.1 | NP_001371720.1 | microtubule-associated protein 4 isoform 28 |
| NM_001384792.1 | NP_001371721.1 | microtubule-associated protein 4 isoform 49 |
| NM_001384793.1 | NP_001371722.1 | microtubule-associated protein 4 isoform 105 |
| NM_001384794.1 | NP_001371723.1 | microtubule-associated protein 4 isoform 82 |
| NM_001384795.1 | NP_001371724.1 | microtubule-associated protein 4 isoform 11 |
| NM_001384796.1 | NP_001371725.1 | microtubule-associated protein 4 isoform 24 |
| NM_001384797.1 | NP_001371726.1 | microtubule-associated protein 4 isoform 43 |
| NM_001384798.1 | NP_001371727.1 | microtubule-associated protein 4 isoform 18 |
| NM_001384800.1 | NP_001371729.1 | microtubule-associated protein 4 isoform 75 |
| NM_001384802.1 | NP_001371731.1 | microtubule-associated protein 4 isoform 128 |
| NM_001384803.1 | NP_001371732.1 | microtubule-associated protein 4 isoform 110 |
| NM_001384804.1 | NP_001371733.1 | microtubule-associated protein 4 isoform 73 |
| NM_001384805.1 | NP_001371734.1 | microtubule-associated protein 4 isoform 121 |
| NM_001384806.1 | NP_001371735.1 | microtubule-associated protein 4 isoform 71 |
| NM_001384807.1 | NP_001371736.1 | microtubule-associated protein 4 isoform 111 |
| NM_001384808.1 | NP_001371737.1 | microtubule-associated protein 4 isoform 129 |
| NM_001384809.1 | NP_001371738.1 | microtubule-associated protein 4 isoform 108 |
| NM_001384810.1 | NP_001371739.1 | microtubule-associated protein 4 isoform 65 |
| NM_001384811.1 | NP_001371740.1 | microtubule-associated protein 4 isoform 118 |
| NM_001384812.1 | NP_001371741.1 | microtubule-associated protein 4 isoform 133 |
| NM_001384813.1 | NP_001371742.1 | microtubule-associated protein 4 isoform 125 |
| NM_001384814.1 | NP_001371743.1 | microtubule-associated protein 4 isoform 44 |
| NM_001384815.1 | NP_001371744.1 | microtubule-associated protein 4 isoform 131 |
| NM_001384816.1 | NP_001371745.1 | microtubule-associated protein 4 isoform 27 |
| NM_001384817.1 | NP_001371746.1 | microtubule-associated protein 4 isoform 130 |
| NM_001384819.1 | NP_001371748.1 | microtubule-associated protein 4 isoform 76 |
| NM_001384820.1 | NP_001371749.1 | microtubule-associated protein 4 isoform 31 |
| NM_001384824.1 | NP_001371753.1 | microtubule-associated protein 4 isoform 59 |
| NM_001384825.1 | NP_001371754.1 | microtubule-associated protein 4 isoform 88 |
| NM_001384826.1 | NP_001371755.1 | microtubule-associated protein 4 isoform 113 |
| NM_001384827.1 | NP_001371756.1 | microtubule-associated protein 4 isoform 79 |
| NM_001384828.1 | NP_001371757.1 | microtubule-associated protein 4 isoform 57 |
| NM_001384831.1 | NP_001371760.1 | microtubule-associated protein 4 isoform 77 |
| NM_001384832.1 | NP_001371761.1 | microtubule-associated protein 4 isoform 45 |
| NM_001384834.1 | NP_001371763.1 | microtubule-associated protein 4 isoform 35 |
| NM_001384835.1 | NP_001371764.1 | microtubule-associated protein 4 isoform 134 |
| NM_001384836.1 | NP_001371765.1 | microtubule-associated protein 4 isoform 48 |
| NM_001384837.1 | NP_001371766.1 | microtubule-associated protein 4 isoform 54 |
| NM_001384838.1 | NP_001371767.1 | microtubule-associated protein 4 isoform 20 |
| NM_001384839.1 | NP_001371768.1 | microtubule-associated protein 4 isoform 89 |
| NM_001384840.1 | NP_001371769.1 | microtubule-associated protein 4 isoform 95 |
| NM_001384841.1 | NP_001371770.1 | microtubule-associated protein 4 isoform 102 |
| NM_001384842.1 | NP_001371771.1 | microtubule-associated protein 4 isoform 114 |
| NM_001384843.1 | NP_001371772.1 | microtubule-associated protein 4 isoform 72 |
| NM_001384844.1 | NP_001371773.1 | microtubule-associated protein 4 isoform 109 |
| NM_001384845.1 | NP_001371774.1 | microtubule-associated protein 4 isoform 101 |
| NM_001384846.1 | NP_001371775.1 | microtubule-associated protein 4 isoform 51 |
| NM_001384847.1 | NP_001371776.1 | microtubule-associated protein 4 isoform 67 |
| NM_001384848.1 | NP_001371777.1 | microtubule-associated protein 4 isoform 65 |
| NM_001384849.1 | NP_001371778.1 | microtubule-associated protein 4 isoform 21 |
| NM_001384850.1 | NP_001371779.1 | microtubule-associated protein 4 isoform 61 |
| NM_001384851.1 | NP_001371780.1 | microtubule-associated protein 4 isoform 97 |
| NM_001384853.1 | NP_001371782.1 | microtubule-associated protein 4 isoform 85 |
| NM_001384856.1 | NP_001371785.1 | microtubule-associated protein 4 isoform 124 |
| NM_001384857.1 | NP_001371786.1 | microtubule-associated protein 4 isoform 90 |
| NM_001384859.1 | NP_001371788.1 | microtubule-associated protein 4 isoform 98 |
| NM_001384861.1 | NP_001371790.1 | microtubule-associated protein 4 isoform 115 |
| NM_001384862.1 | NP_001371791.1 | microtubule-associated protein 4 isoform 123 |
| NM_001384863.1 | NP_001371792.1 | microtubule-associated protein 4 isoform 47 |
| NM_001384864.1 | NP_001371793.1 | microtubule-associated protein 4 isoform 60 |
| NM_001384866.1 | NP_001371795.1 | microtubule-associated protein 4 isoform 99 |
| NM_001384867.1 | NP_001371796.1 | microtubule-associated protein 4 isoform 91 |
| NM_001384868.1 | NP_001371797.1 | microtubule-associated protein 4 isoform 46 |
| NM_001384869.1 | NP_001371798.1 | microtubule-associated protein 4 isoform 78 |
| NM_001384870.1 | NP_001371799.1 | microtubule-associated protein 4 isoform 93 |
| NM_001384871.1 | NP_001371800.1 | microtubule-associated protein 4 isoform 29 |
| NM_001384872.1 | NP_001371801.1 | microtubule-associated protein 4 isoform 68 |
| NM_001384873.1 | NP_001371802.1 | microtubule-associated protein 4 isoform 33 |
| NM_001384874.1 | NP_001371803.1 | microtubule-associated protein 4 isoform 64 |
| NM_001384875.1 | NP_001371804.1 | microtubule-associated protein 4 isoform 19 |
| NM_001384876.1 | NP_001371805.1 | microtubule-associated protein 4 isoform 42 |
| NM_001384877.1 | NP_001371806.1 | microtubule-associated protein 4 isoform 126 |
| NM_001384878.1 | NP_001371807.1 | microtubule-associated protein 4 isoform 96 |
| NM_001384879.1 | NP_001371808.1 | microtubule-associated protein 4 isoform 5 |
| NM_001384892.1 | NP_001371821.1 | microtubule-associated protein 4 isoform 37 |
| NM_001384893.1 | NP_001371822.1 | microtubule-associated protein 4 isoform 103 |
| NM_001385664.1 | NP_001372593.1 | microtubule-associated protein 4 isoform 9 |
| NM_001385665.1 | NP_001372594.1 | microtubule-associated protein 4 isoform 18 |
| NM_001385675.1 | NP_001372604.1 | microtubule-associated protein 4 isoform 34 |
| NM_001385676.1 | NP_001372605.1 | microtubule-associated protein 4 isoform 107 |
| NM_001385677.1 | NP_001372606.1 | microtubule-associated protein 4 isoform 44 |
| NM_001385681.1 | NP_001372610.1 | microtubule-associated protein 4 isoform 25 |
| NM_001385682.1 | NP_001372611.1 | microtubule-associated protein 4 isoform 6 |
| NM_001385684.1 | NP_001372613.1 | microtubule-associated protein 4 isoform 53 |
| NM_001385685.1 | NP_001372614.1 | microtubule-associated protein 4 isoform 69 |
| NM_001385686.1 | NP_001372615.1 | microtubule-associated protein 4 isoform 13 |
| NM_001385687.1 | NP_001372616.1 | microtubule-associated protein 4 isoform 2 |
| NM_001385688.1 | NP_001372617.1 | microtubule-associated protein 4 isoform 8 |
| NM_001385689.1 | NP_001372618.1 | microtubule-associated protein 4 isoform 7 |
| NM_001385690.1 | NP_001372619.1 | microtubule-associated protein 4 isoform 135 |
| NM_001385691.1 | NP_001372620.1 | microtubule-associated protein 4 isoform 135 |
| NM_001385692.1 | NP_001372621.1 | microtubule-associated protein 4 isoform 135 |
| NM_002375.5 | NP_002366.2 | microtubule-associated protein 4 isoform 1 |
| NM_030885.4 | NP_112147.2 | microtubule-associated protein 4 isoform 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables microtubule stabilizing activity |
IDA
IDA: Inferred from direct assay
|
34782749 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17474147 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within cell division |
IMP
IMP: Inferred from mutant phenotype
|
21822276 | GOA |
| involved in cilium disassembly |
IDA
IDA: Inferred from direct assay
|
34782749 | GOA |
| acts upstream of or within establishment of spindle orientation |
IGI
IGI: Inferred from genetic interaction
|
21822276 | GOA |
| acts upstream of or within establishment of spindle orientation |
IMP
IMP: Inferred from mutant phenotype
|
21822276 | GOA |
| involved in microtubule cytoskeleton organization |
IDA
IDA: Inferred from direct assay
|
34782749 | GOA |
| involved in microtubule polymerization |
IDA
IDA: Inferred from direct assay
|
10791892 | GOA |
| acts upstream of or within microtubule sliding |
IMP
IMP: Inferred from mutant phenotype
|
21822276 | GOA |
| acts upstream of or within mitotic spindle organization |
IMP
IMP: Inferred from mutant phenotype
|
21822276 | GOA |
| involved in negative regulation of non-motile cilium assembly |
IMP
IMP: Inferred from mutant phenotype
|
23572511 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in axoneme |
IDA
IDA: Inferred from direct assay
|
23572511 | GOA |
| is active in microtubule |
IDA
IDA: Inferred from direct assay
|
34782749 | GOA |
| located in microtubule organizing center |
IDA
IDA: Inferred from direct assay
|
29180244 | GOA |
| located in mitotic spindle |
IDA
IDA: Inferred from direct assay
|
21822276 | GOA |
MAP4 Protein Structure
Tubulin-binding: Tau and MAP protein, tubulin-binding repeat (924 - 953)
Tubulin-binding: Tau and MAP protein, tubulin-binding repeat (992 - 1022)
Tubulin-binding: Tau and MAP protein, tubulin-binding repeat (1023 - 1053)
Tubulin-binding: Tau and MAP protein, tubulin-binding repeat (1054 - 1084)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1152 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
microtubule-associated protein 4 |
|
MAP4 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MAP4 | P27816 | CAPN1 | Homo sapiens | P07384 | 35271311 | |
|
Intra
|
MAP4 | P27816 | CAPN1 | Homo sapiens | P07384 | 33961781 | |
|
Intra
|
MAP4 | P27816 | NCK1 | Homo sapiens | P16333 | 17474147 |
MAP4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P89851 | MAP-4 Antibody (YA9195) | WB, ICC/IF, IF-Tissue, IP | human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Dystonia 11, Myoclonic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | MAP4 | VGNC | VGNC:102633 |
| Rattus norvegicus | MAP4 | RGD | RGD:1564359 |
| Macaca mulatta | MAP4 | VGNC | VGNC:110353 |
| Mus musculus | MAP4 | MGD | MGI:97178 |
| Canis familiaris | MAP4 | VGNC | VGNC:81276 |
| Others | MAP4 | NCBI |