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Ccr2 - C-C motif chemokine receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 60463

About Ccr2

Primary_assembly 8: 123,734,430-123,742,100 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 151 orthologues, 24 paralogues and is associated with 93 phenotypes.

Ccr2 Products (1)

mRNA	Protein	Name
NM_021866.2	NP_068638.1	C-C chemokine receptor type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15978006	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18584881	RGD
involved in blood vessel remodeling	IEP IEP: Inferred from expression pattern	15178559	RGD
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18584881	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16174730	RGD
involved in inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	14674010	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	15978006	RGD
involved in positive regulation of NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	27094552	RGD
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	18584881	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24826069	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	21404274	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18446360	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	15978006	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15978006	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16196033	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15978006	RGD
located in primary dendrite	IDA IDA: Inferred from direct assay	16196033	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr2 Protein Structure

7tmA_CCR5_CCR2

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 2	C-C CKR-2 CC-CKR-2 CCR-2 chemokine (C-C motif) receptor 2 chemokine receptor CCR2

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1076	Medrysone	Activator	99.79%	Unkown
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	Unkown
HY-117621	PF-04634817	Antagonist	98.87%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.51%	Phase 3
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.94%	Phase 3
HY-13245	PF-4136309	Antagonist	99.86%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-101713	Ilacirnon	Inhibitor	98.05%	Phase 2
HY-50669A	MK-0812 Succinate	Antagonist	99.94%	Phase 2

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	99.53%	Phase 2

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15418	RS 504393	Antagonist	99.72%	Unkown
HY-50674	INCB3344	Antagonist	99.81%	Unkown
HY-13406	TAK-779	Antagonist	99.89%	Unkown
HY-18611A	Abaucin	Antagonist	99.59%	Unkown
HY-18611	Abaucin hydrochloride	Antagonist	99.94%	Unkown
HY-108323	CCR2 antagonist 4	Antagonist	99.89%	Unkown
HY-50081	CCR2-RA-[R]	Antagonist	99.21%	Unkown
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-15450A	INCB 3284	Antagonist	99.30%	Unkown
HY-103362	CCR2 antagonist 4 hydrochloride	Antagonist	99.91%	Unkown
HY-101908	BMS CCR2 22	Antagonist	99.27%	Unkown
HY-50669	MK-0812	Antagonist	99.89%	Yes
HY-135891	AZD2423	Antagonist	99.91%	Unkown
HY-101264	CCR2 antagonist 3	Antagonist	99.91%	Unkown
HY-402739	CCR2-IN-1	Inhibitor	/	Unkown
HY-13499	JNJ-41443532	Inhibitor	99.65%	Unkown
HY-110132	JNJ-27141491	Antagonist	97.01%	Unkown
HY-112792	CCR2 antagonist 1	Antagonist	95.04%	Unkown
HY-50674A	INCB3344 R-isomer		98.01%	Unkown
HY-P11553B	DOTA-ECL1i	Inhibitor	98.06%	Unkown
HY-15450	INCB 3284 dimesylate	Antagonist	≥98.0%	Unkown
HY-100819	RO5234444	Antagonist	/	Unkown
HY-P11553	ECL1i	Inhibitor	/	Unkown
HY-171685	Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA	Antagonist	/	Unkown
HY-136768	YJC-10592	Antagonist	/	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown
HY-171682	Anti-CCL2 (Carlumab)-McMMAF	Antagonist	/	Unkown
HY-180572	CCR2 ligand-1	Ligand	/	Unkown
HY-171681	Anti-CCL2 (Carlumab)-SPDB-DM4	Antagonist	/	Unkown
HY-171680	Anti-CCL2 (Carlumab)-SMCC-DM1	Antagonist	/	Unkown
HY-N17908	Viscumneoside V	Inhibitor	98.24%	Unkown
HY-179607	LUF8100	Antagonist	98.64%	Unkown
HY-50084	CCR2-RA	Antagonist	/	Unkown
HY-129991	JNJ-17166864	Antagonist	/	Unkown
HY-180571	LUF7996	Degrader	/	Unkown
HY-171684	Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38	Antagonist	/	Unkown
HY-119658	PF-4178903	Antagonist	/	Unkown
HY-19009B	Propagermanium	Inhibitor	/	Unkown
HY-108432	BMS-741672	Antagonist	/	Unkown
HY-185299	CCR2 antagonist 6	Antagonist	/	Unkown
HY-148100C	Emapticap pegol scramble negative control	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr2	NCBI	NCBI:729230